Search for dissertations about: "Gastrin-releasing peptide receptor GRPR"

Found 4 swedish dissertations containing the words Gastrin-releasing peptide receptor GRPR.

  1. 1. Bombesin Antagonists for Targeting Gastrin-Releasing Peptide Receptor-Positive Tumors Design, Synthesis, Preclinical Evaluation and Optimization of Imaging Agents

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Zohreh Varasteh; Uppsala universitet.; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bombesin; Gastrin-releasing peptide receptor GRPR ; Antagonist; Radionuclide molecular imaging;

    Abstract : This thesis is focused on the development, preclinical evaluation, and optimization of radiotracers for the detection of gastrin-releasing peptide receptor (GRPR)-expressing tumors. The work is divided into three distinct parts: (1) the development of bombesin (BN) antagonist (RM26)-based imaging radiotracers for the detection of GRPR-expressing tumors using different positron emission tomography (PET) and single photon emission computed tomography (SPECT) radionuclides (68Ga, 18F and 111In), (2) the establishment of a method to monitor the ligand-G protein-coupled receptor (GPCR) interaction in real time without requiring purification and stabilization of the receptors, and (3) the evaluation of radiopeptide structure-related factors (length of mini-PEG linker and composition of chelator for metal labeling) affecting the in vitro and in vivo characteristics of RM26-based tracers. READ MORE

  2. 2. Prostate cancer theranostics using GRPR antagonist RM26

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Bogdan Mitran; Uppsala universitet.; [2019]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gastrin-releasing peptide receptor GRPR ; Bombesin; Prostate-specific membrane antigen PSMA ; Antagonist; Radionuclide molecular imaging; Theranostics; Peptide receptor radionuclide therapy PRRT .;

    Abstract : The malignant transformation of cells is often associated with an alteration of their molecular phenotype, resulting in overexpression of several cell surface proteins. Gastrin-releasing peptide receptor (GRPR) and prostate-specific membrane antigen (PSMA) are examples of such pro-teins that are expressed at a high density in prostate cancer. READ MORE

  3. 3. Functional Aspects of Peripheral and Spinal Cord Neurons Involved in Itch and Pain

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Bejan Aresh; Uppsala universitet.; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mGluR7; anaphylaxis; Grpr; Penk; Pdyn; Cre line; BAC cloning; spinal cord; transgenic line; Medicinsk vetenskap; Medical Science;

    Abstract : We have investigated the role of the metabotropic glutamate receptor 7 (mGluR7) and the gastrin releasing peptide receptor (Grpr) population that are involved at different levels of itch transmission. We found that mGuR7 deficient mice displayed an anaphylaxis-like behavior when provoked with histamine. READ MORE

  4. 4. The neuropeptides GRP and PACAP and the function of the endocrine pancreas - A study on receptor deficient mice

    University dissertation from Kristin Persson, Tullg 9, S-22354 Lund, Sweden

    Author : Kristin Persson; Lund University.; Lunds universitet.; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; hypoglycemia; glucagon; insulin; islet of Langerhans; diabetes; PACAP; neuropeptides; GRP; diabetologi;

    Abstract : The parasympathetic nerves are important for the regulation of insulin secretion, in particular after meal intake. Apart from acetylcholine, several neuropeptides can be found in the parasympathetic nerves innervating the islets of Langerhans, including gastrin-releasing peptide (GRP) and pituitary adenylate cyclase activating polypeptide (PACAP). READ MORE