Search for dissertations about: "Gemfibrozil"

Found 4 swedish dissertations containing the word Gemfibrozil.

  2. 1. The Hepatobiliary Transport of Rosuvastatin In Vivo

    Author : Ebba Bergman; Hans Lennernäs; Ulf Bondesson; Jack Cook; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rosuvastatin; Biliary excretion; Transport inhibition; Pharmacokinetics; Drug-drug interactions; Hepatobiliary transport; Organic anion transporting polypeptide; OATP; Statins; Gemfibrozil; Cyclosporine; Imatinib; Rifampicin; Canalicular transport; Sinusoidal transport; Hepatic uptake; Hepatic extraction; Biopharmacy; Biofarmaci; Biopharmaceutics; biofarmaci;

    Abstract : In vivo studies of hepatobiliary disposition are challenging. The hepatobiliary system is complex, as its physiological localization, complex cellular structure with numerous transporters and enzymes, and the interindividual variability in protein expression and biliary flow will all affect the in vivo disposition of a drug under investigation. READ MORE

  4. 2. Platelet function in hyperlipoproteinemia and effects of lipid-lowering treatment

    Author : Anders Bröijersén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Coronary atherosclerosis and thrombus formation on fissuring atherosclerotic plaques are key events in the development of coronary artery disease. Hyperlipoproteinemia induces atherosclerosis but may also exert direct prothrombotic effects via platelet activation. READ MORE

  5. 3. Modulation of bile acid and cholesterol metabolism in health and disease

    Author : Cecilia Gälman; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Bile acids - cholesterol - gallstone - cholic acid - cholestyramine - high performance liquid chromatography - species - C4 - 7alpha-hydroxy-4-cholesten-3 -one cholesterol 7alpha-hydroxylase - lipoproteins - hyperlipidemia - statins - resins - diurnal variation - ASBT - 3-hydroxy-3-methylglutaryl coenzyme A;

    Abstract : An increased level of plasma cholesterol is associated with premature development of atherosclerosis. It is therefore important to understand the regulation of plasma cholesterol. Stimulation of hepatic bile acid synthesis is a strategy to reduce plasma cholesterol. This partly occurs due to an induction of hepatic LDL receptors. READ MORE

  6. 4. Regulation of plasminogen activator inhibitor-1 : role of triglyceride-rich lipoproteins, fatty acids and fibrate compounds

    Author : Lennart Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : plasminogen activator inhibitor-1; coronary heart disease; endothelial cells; very low density lipoprotein VLDL ; 4G 5G polymorphism; VLDL response element; fibrate compounds; VLDL receptor; stroke;

    Abstract : Impaired fibrinolytic function secondary to elevated plasma plasminogen activator inhibitor-1 (PAI-1) activity is associated with atherothrombotic disease, in particular coronary heart disease. Both environmental and genetic factors contribute to determine plasma PAI-1 levels and PAI-1 production in vivo. READ MORE