Search for dissertations about: "Gene down-regulation"

Showing result 1 - 5 of 156 swedish dissertations containing the words Gene down-regulation.

2. 1. Chemically Modified Oligonucleotides: Synthesis, Physicochemical and Biochemical Properties of their Duplexes with DNA and RNA

   Author : Pushpangadan Indira Pradeepkumar; Jyoti Chattopadhyaya; Jesper Wengel; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Bioorganic chemistry; Antisense oligonucleotides; Dipyridophenazine; Oxetane; RNase H; Gene down-regulation; DNase 1; Charge transport; Bioorganisk kemi; Bioorganic chemistry; Bioorganisk kemi;

   Abstract : This thesis is based on 9 papers dealing with the synthesis, physicochemical and biochemical properties of two types of chemically modified oligonucleotides which have the potential to down-regulate gene expression: (i) The first set is comprised of antisense oligonucleotides (AONs) conjugated with different chromophores of varying size, charge and π-electron density. Conjugation of the chromophores at the 3'- or 5'-end enhanced the target RNA binding affinity and RNase H recruitment capabilities compared to the native counterpart without changing the global helical conformation of their AON/RNA hybrid duplexes. READ MORE

4. 2. Gene expression in carcinogenesis

   Author : Heléne Fischer; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : It is important to understand the processes of carcinogenesis and to find out which genes are involved . One way to study the process on a molecular basis is to identify differences in gene expression. READ MORE

5. 3. Genetic diversity of the heat labile (LT) and heat stable (ST) toxins of human enterotoxigenic Escherichia coli (ETEC): New insights into polymorphism, regulation, and gene transcription

   Author : Enrique Joffre; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ETEC; diversity; bacterial enterotoxins; polymorphism; gene regulation; gene transcription; Diarrhoeal disease; bacterial infection;

   Abstract : Infection with enterotoxigenic Escherichia coli (ETEC) is a leading cause of diarrhea in children in developing countries and travelers to endemic regions. ETEC is a diverse pathogen, with a wide range of virulence factors including enterotoxins and more than 25 identified colonization factors (CFs). READ MORE

6. 4. Gene Therapy with Interferon Alpha and the Angiogenic Inhibitor, Vasostatin, in Neuroendocrine Tumors of the Digestive System

   Author : Minghui Liu; Kjell Oberg; Yinghua Zhou; Bertram Wiedenmann; Uppsala universitet; []
   Keywords : Internal medicine; neuroendocrine tumor; interferon-α; vasostatin; vinculin; tumor suppressor gene; nude mice; gene therapy; Invärtesmedicin;

   Abstract : IFN-α has been applied in medical treatment of various neuroendocrine (NE) tumors, either alone or combination with somatostatin analogues. They can improve clinical symptoms in 50-70% of patients but a significant tumor reduction is only observed in 5-15% patients. Vasostatin (vaso) is believed to be an angiogenic inhibitor. READ MORE

7. 5. Thioredoxins and gene regulation in the Drosophila germline

   Author : Malin J. Svensson; Jan Larsson; David Roberts; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Drosophila; thioredoxin; sex-specific; Pof; chromosome 4; gene regulation; kromosom 4; genreglering; Drosophila; thioredoxin; könsspecifik; Pof; Molecular biology; Molekylärbiologi;

   Abstract : Spermatogenesen är i många organismer en av de mest dramatiska förvandlingar som en cell kan genomgå – en vanlig, rund, diploid cell omvandlas till en nålformad, haploid cell med ett tätt packat cellmaskineri. I bananfluga, Drosophila melanogaster, innebär denna process flera karaktäristiska stadier. READ MORE