Search for dissertations about: "Gene duplication"

Showing result 21 - 25 of 112 swedish dissertations containing the words Gene duplication.

  2. 21. The Gene Repertoire of G protein-coupled Receptors : New Genes, Phylogeny, and Evolution

    Author : Þóra Kristín Bjarnadóttir; Helgi B. Schiöth; Robert Fredriksson; Kurt Kristiansen; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; Bioinformatics; Evolution; GPCR; Phylogeny; Farmakologi; Pharmacological research; Farmakologisk forskning;

    Abstract : The superfamily of G protein-coupled receptors (GPCRs) is one of the largest protein families of mammalian genomes and can be divided into five main families; Glutamate, Rhodopsin, Adhesion, Frizzled, and Secretin. GPCRs participate in most major physiological functions, contributing to the fact that they are important targets in drug discovery. READ MORE

  4. 22. Genome instability, gene expression and prognosis in breast cancer

    Author : Ulrike Kronenwett; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Breast adenocarcinoma; genomic instability; SSI; centrosomes;

    Abstract : Aneuploid cancers are regarded as being more malignant than tumors of other ploidy categories, and they are characterized by increased genomic instability. Our investigations resulted in the characterization of an aneuploid subtype of breast carcinoma that proved to be genomically stable. READ MORE

  5. 23. Exploring the role of gene duplications in plant-insect interactions

    Author : Hanna Nicole Dort; Christopher Wheat; Noah Whiteman; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; plant-insect interactions; comparative genomics; detoxification; transcriptomics; nitrile-specifier proteins; butterflies; populationsgenetik; Population Genetics;

    Abstract : As evolutionary biologists, we are often curious about the genomic origins of our favorite adaptations. Although some innovations certainly arose de novo, many more originated through the process of whole-gene or within-gene duplication. READ MORE

  6. 24. Probabilistic Models for Species Tree Inference and Orthology Analysis

    Author : Ikram Ullah; Jens Lagergren; Arndt von Haeseler; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; phylogenetics; phylogenomics; gene tree; species tree; expectation maximization; mixture model; dynamic programming; markov chain monte carlo; PrIME; JPrIME; Datalogi; Computer Science;

    Abstract : A phylogenetic tree is used to model gene evolution and species evolution using molecular sequence data. For artifactual and biological reasons, a gene tree may differ from a species tree, a phenomenon known as gene tree-species tree incongruence. Assuming the presence of one or more evolutionary events, e.g. READ MORE

  7. 25. Genomic and phenotypic consequences of allopolyploidization in Capsella

    Author : Tianlin Duan; Martin Lascoux; Adrien Sicard; Sylvain Glémin; Barbara Mable; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Allopolyploidy; Polyploidy; Hybridization; Neopolyploid lines; Gene expression; Self-incompatibility; Capsella bursa-pastoris;

    Abstract : Allopolyploidization, the combination of whole-genome duplication (WGD) and interspecific hybridization, is a frequent and influential event in plant evolution. Allopolyploidization potentially affects both adaptation and diversification, yet the understanding of the consequences of allopolyploidy has been obscured by several issues. READ MORE