Search for dissertations about: "Gene order rearrangements"

Showing result 16 - 20 of 27 swedish dissertations containing the words Gene order rearrangements.

  2. 16. Study on the Function of Translation Initiation Factor IF1

    Author : Victor Croitoru; Leif A. Isaksson; Kim Kusk Mortensen; Stockholms universitet; []
    Keywords : translation; initiation factor IF1; mutagenesis; A-site; RNA chaperone; NATURAL SCIENCES; NATURVETENSKAP;

    Abstract : Initiation is the first step in protein biosynthesis representing a fundamental event in cell life which determines fidelity, efficiency and regulation of gene expression. In addition to the ribosome and mRNA, three protein factors IF1, IF2 and IF3 are involved in the initiation of translation in prokaryotes. READ MORE

  4. 17. Genetic studies of acute lymphoblastic leukemia

    Author : Ekaterina Kuchinskaya; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy, comprising approximately 25% of all childhood cancers. A huge improvement in outcome of children with ALL during the last 20 years has resulted in remission rates exceeding 95% and a 5 year event-free-survival approaching 80%. READ MORE

  5. 18. Characterisation of chromosomal aberrations in childhood leukaemia

    Author : Ann Nordgren; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Chromosome aberrations; SKY; interphase-FISH; Childhood ALL;

    Abstract : Acute lymphoblastic leukaemia (ALL) is the most common malignancy in childhood, accounting for approximately 25% of all paediatric malignancies. Based on clinical risk criteria and modem laboratory investigations including immunophenotyping, cytogenetics, and molecular genetics, patients can be divided into prognostic groups and assigned to risk- adjusted treatment protocols. READ MORE

  6. 19. Perks and considerations when targeting functional non-coding regions with CRISPR/Cas9

    Author : Keyi Geng; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Since the CRISPR system was discovered as an adaptive immune response in prokaryotic cells, the past decade has witnessed the engineering and deployment of CRISPR/Cas9 as one of the most efficient and powerful molecular tools. By leveraging the nuclease activity of CRISPR/Cas9, researchers are able to probe the biological functions of genetic elements and dissect molecular interactions by disrupting, activating or inactivating genes. READ MORE

  7. 20. Characterization of human chromosome 22 : cloning of breakpoints of the constitutional translocation t(11;22)(q23;q11) and detection of small constitutional delections by microarray CGH

    Author : Isabel Tapia Paez; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Chromosome 22; t 11; 22 q23; q 11 ; inverted repeats palindromes; DiGeorge Velo-cardio-facial syndrome; array-CGH;

    Abstract : Chromosome 22 is the second smallest human chromosome, composing approximately 1.5% of the genome. The short arm of this acrocentric chromosome harbors ribosomal genes and the long arm contains the protein coding genes. READ MORE