Search for dissertations about: "Gene overexpression"

Showing result 1 - 5 of 287 swedish dissertations containing the words Gene overexpression.

2. 1. Gene Expression Studies of Hematologic Malignacies

   Author : Anna Andersson; Avdelningen för klinisk genetik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellular fluids; Haematology; cancer; onkologi; Cytologi; oncology; Cytology; acute myeloid leukemia; acute lymphoblastic leukemia; normal hematopoietic cells; cDNA microarray; gene expression profiling; hematopoiesis; pediatric leukemia; fusion gene; Pediatrics; Pediatri; Clinical genetics; Klinisk genetik; cancerology; Hematologi; extracellulära vätskor;

   Abstract : The general aim of this thesis was to characterize hematologic malignancies using gene expression profiling in order to obtain an improved classification and to study deregulated transcriptional networks in leukemia. In the first study (Article I), the gene expression profiles of hematologic cell lines were analyzed to investigate whether such cell lines maintain expression profiles that are characteristic of their primary genetic changes. READ MORE

4. 2. Biochemical and Physiological Characterization of Nonsymbiotic Plant Hemoglobins

   Author : Nélida Leiva; Tillämpad biokemi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Hemoglobin; Non-symbiotic hemoglobin; Sugar beet; Ligand binding; Nitric oxide; Gene expression; Gene overexpression; Poplar; Arabidopsis; Lepidium campestre.;

   Abstract : Hemoglobins (Hb) are usually associated with blood in humans. However, these proteins are widely distributed among living organisms. In plants the most known group are the leghemoglobins. Still, other Hbs that not participate in symbiosis are also found. READ MORE

5. 3. Cellular Resilience and Fragility in Response to Environmental and Gene Expression Perturbations

   Author : Lars-Göran Ottosson; Göteborgs universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Saccharomyces cerevisiae; Phenomics; Liquid microcultivation; Tellurite; Gene overexpression; gToW; Cellular signalling; HOG; Protein phosphatase;

   Abstract : Cells are constantly subjected to perturbations. Whether these are extracellular or intracellular, they can be detrimental to cellular fitness. The cell has evolved elaborate systems and mechanisms that allow it to remain functional in the face of disturbances. READ MORE

6. 4. Animal genomics – gene discovery and gene characterization

   Author : Rakan Naboulsi; Leif Andersson; Mårten Larsson; Susanne Kerje; Tosso Leeb; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Spontaneous autoimmune thyroiditis; SAT; Hashimoto’s thyroiditis; HT; Obese strain; transcriptional regulation; ZBED6; Igf2; miRNA; miR483; Whole-genome sequencing; RNA-seq; miRNA-seq;

   Abstract : This thesis involves two projects. The aim in the first project was to identify genomic regions associated with spontaneous autoimmune thyroiditis (SAT), which is a hereditary autoimmune disease that affects the obese strain (OS) of chicken, an animal model for human Hashimoto’s thyroiditis (HT). READ MORE

7. 5. Myocardial gene therapy and gene expression in angina pectoris

   Author : Andreas Rück; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Angina pectoris; gene therapy; vascular endothelial growth factor; plasmid; prognosis; collaterals; angiogenesis; gene expression; microarray; natriuretic peptides.;

   Abstract : Background: Angiogenesis does not fully counteract myocardial ischemia in stable angina pectoris. Refractory angina pectoris, with remaining symptoms despite medication and no possibility for bypass surgery or angioplasty, is rather common. Angiogenic gene therapy is a novel treatment strategy for these patients. READ MORE