Search for dissertations about: "Gene-disruption"

Showing result 1 - 5 of 8 swedish dissertations containing the word Gene-disruption.

  1. 1. Surface proteins of Finegoldia magna interacting with the human host

    University dissertation from Department of Clinical Sciences, Lund University

    Author : Christofer Karlsson; Lunds universitet.; Lund University.; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Finegoldia magna; Gram-positive anaerobic cocci; surface proteins; protease; LL-37; MIG CXCL9; Fibrinogen; adhesion; gene disruption; bacterial aggregation; basement membranes;

    Abstract : Finegoldia magna is a Gram-positive anaerobe and a member of the normal human microflora. This bacterium is also an opportunistic pathogen and isolated from ~10% of all anaerobic infections. Reoccurring taxonomical changes and the anaerobic growth have contributed to the neglect of F. magna. READ MORE

  2. 2. Extracellular serine proteases as virulence factors in nematophagous fungi: Molecular characterization and functional analysis of the PII protease in Arthrobotrys oligospora

    University dissertation from Microbial Ecology, Lund University

    Author : Johan Åhman; Lunds universitet.; Lund University.; [2000]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biology; Aspergillus niger.; Heterologous expression; Over-expression; Gene-disruption; Transformation system; Serine protease; Biological control; Arthrobotrys oligospora; Fungi; Nematophagous; Biologi;

    Abstract : Nematophagous fungi are parasites of nematodes, thus they have been considered and tested for biological control of parasitic nematodes, but so far with limited success. Due to the fact that the nematode cuticle is composed of proteins it is likely that fungal extracellular proteases are involved in the infection of nematodes. READ MORE

  3. 3. Pericyte recruitment and functions in vivo. Studies of platelet-derived growth factor-B deficient embryos

    University dissertation from Göteborg

    Author : Mats Hellström; Göteborgs universitet.; Gothenburg University.; [2000]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mouse; gene targeting; platelet-derived growth factor; pericyte; vascular smooth muscle; angiogenesis;

    Abstract : A functional vascular system is essential for tissue growth and maintenance, and the circulatory system is therefore the first operational organ of the vertebrate embryo. In conditions of pathological tissue growth, such as tumors, formation of new blood vessels is also required, and it is anticipated that prevention of blood vessel development in those settings might ameliorate the disease progress. READ MORE

  4. 4. Structural genomic variation in human disease

    University dissertation from Stockholm : Karolinska Institutet, Dept of Molecular Medicine and Surgery

    Author : Maria Pettersson; Karolinska Institutet.; Karolinska Institutet.; [2019]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Structural variants (SVs) are physical changes in the structure of chromosomes and include both unbalanced copy number variants (CNVs) and balanced events (translocations, inversions and insertions). Many SVs constitute benign background variation and are found frequently in healthy individuals. READ MORE

  5. 5. Programming Blood Cell Fates. Insights from Direct Lineage Conversion and Development

    University dissertation from Lund University, Faculty of Medicine

    Author : Sandra Capellera Garcia; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; [2018]
    Keywords : Hematopoietic development; Erythropoiesis; Megakaryopoiesis; Direct Lineage Conversion;

    Abstract : Red blood cells (RBC) and platelets constitute the non-immune branch of the hematopoietic system and are responsible for the vital functions of transporting oxygen to the tissues and clotting blood vessel injuries, respectively. These cells are produced during embryonic development and throughout life through a process called hematopoiesis which is tightly regulated by extrinsic and intrinsic factors. READ MORE