Search for dissertations about: "Gene-environment interactions"

Showing result 21 - 25 of 32 swedish dissertations containing the words Gene-environment interactions.

  2. 21. The role of the serotonergic system and the effects of antidepressants during brain development examined using in vivo PET imaging and in vitro receptor binding

    Author : Stal Saurav Shrestha; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Serotonin (5-HT) and the serotonergic system, which includes the serotonin transporter (SERT) and the two G protein-coupled 5-HT1A and 5-HT1B receptors, are implicated in the pathophysiology and treatment of several neuropsychiatric disorders including major depressive disorder (MDD) and anxiety. Two classes of antidepressants—selective serotonin reuptake inhibitors (SSRIs), which block SERT, and tricyclic antidepressants (TCAs), which block several monoamine transporters—alter 5-HT levels and modulate the serotonergic system. READ MORE

  4. 22. Genetic Contributions to Manifestations and Prognosis of Systemic Lupus Erythematosus

    Author : Sarah Reid; Dag Leonard; Timothy Niewold; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Systemic lupus erythematosus; genetics; cardiovascular disease; polygenic risk score; smoking; Medicinsk vetenskap; Medical Science;

    Abstract : Systemic lupus erythematosus (SLE) is a severe autoimmune disease with a multifactorial aetiology and an extremely heterogenous clinical picture. This thesis explores the impact of SLE genetic variants, through their cumulative effect or gene-environment interactions, on SLE manifestations and complications. READ MORE

  5. 23. Genetic vulnerability, environmental exposures and neurodevelopmental disorders : clinical insights and in-vitro consequences

    Author : Abishek Arora; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : An understanding of how different genetic backgrounds and environmental exposures interact and contribute to diverse medical conditions like neurodevelopmental disorders (NDDs), is key to better health outcomes. A considerable overlap exists in the underlying genetics and physiology, often leading to their co-diagnoses. READ MORE

  6. 24. Genetic variability commonly affecting neurodegeneration and neuroinflammation

    Author : Mikael Ström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Loss of nerve cells and axons is a common feature of common complex neurodegenerative disorders, such as Alzheimer’s and Parkinson’s diseases. However, also Multiple Sclerosis (MS), primarily an autoimmune disorder, has a prominent neurodegenerative component. READ MORE

  7. 25. Early life experiences and alcohol use in youth : An emerging role of the Vesicular Glutamate Transporters

    Author : Maria Vrettou; Erika Comasco; Ingrid Nylander; Kent W. Nilsson; Åsa Wallén-Mackenzie; Roberto Ciccocioppo; Uppsala universitet; []
    Keywords : alcohol; early-life stress; brain; early adulthood; expression; DNA methylation; glutamate; Vesicular Glutamate Transporters;

    Abstract : Initiation of alcohol consumption usually takes place during adolescence, a period characterized by a plethora of physical and emotional changes. Towards early adulthood, hazardous drinking patterns can emerge and potentially lead to the development of Alcohol Use Disorder (AUD). READ MORE