Search for dissertations about: "Gene-expression"

Showing result 6 - 10 of 2113 swedish dissertations containing the word Gene-expression.

  2. 6. Gene Expression Studies of Hematologic Malignacies

    Author : Anna Andersson; Avdelningen för klinisk genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellular fluids; Haematology; cancer; onkologi; Cytologi; oncology; Cytology; acute myeloid leukemia; acute lymphoblastic leukemia; normal hematopoietic cells; cDNA microarray; gene expression profiling; hematopoiesis; pediatric leukemia; fusion gene; Pediatrics; Pediatri; Clinical genetics; Klinisk genetik; cancerology; Hematologi; extracellulära vätskor;

    Abstract : The general aim of this thesis was to characterize hematologic malignancies using gene expression profiling in order to obtain an improved classification and to study deregulated transcriptional networks in leukemia. In the first study (Article I), the gene expression profiles of hematologic cell lines were analyzed to investigate whether such cell lines maintain expression profiles that are characteristic of their primary genetic changes. READ MORE

  4. 7. Gene Expression and DNA Methylation in Acute Lymphoblastic Leukemia

    Author : Jessica Nordlund; Syvänen Ann-Christine; Xavier Estivill; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Digital gene expression; Allele-specific gene expression; DNA methylation; Epigenetics; Acute lymphoblastic leukemia; Molekylär medicin; Molecular Medicine;

    Abstract : Pediatric acute lymphoblastic leukemia (ALL) is the most common malignancy in children, which results from the malignant transformation of progenitor cells in the bone marrow into leukemic cells. The precise mechanisms for this transformation are not well defined, however recent studies suggest that aberrant regulation of gene expression or DNA methylation may play an important role. READ MORE

  5. 8. Sexual Conflict and Gene Expression in Drosophila melanogaster

    Author : Paolo Innocenti; Edward Morrow; Göran Arnqvist; Andrew G Clark; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Sexual conflict; sexual selection; male-female coevolution; gene expression; transcriptome; microarrays; sexual dimorphism; Drosophila; Biology; Biologi; Biologi med inriktning mot zooekologi; Biology with specialization in Animal Ecology; Biology with specialization in Evolutionary Genetics; Biologi med inriktning mot evolutionär genetik;

    Abstract : Sexual conflict is broadly defined as a conflict between the evolutionary interests of the two sexes. Depending on the genetic architecture of the traits involved, it can occur at the level of male-female interactions or take the form of selection acting to change the mean of a shared trait against the sign of its genetic correlation. READ MORE

  6. 9. Regulation of chloroplast gene expression in higher plants

    Author : Anna Furo Tullberg; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; protein tyrosine kinase; plastoquinone pool; redox; Pisum sativum; Sinapis alba; petB; psaB; chloroplast; gene expression; Physiological biophysics; Växtfysiologi; light harvesting complex II;

    Abstract : Chloroplast gene expression is regulated by developmental and environmental signals. It has been proposed that there is a direct coupling between electron transport in biological membranes and gene expression (J. F. Allen, 1992, Biochim. READ MORE

  7. 10. Adipose tissue gene expression & candidate genes for obesity

    Author : Lovisa Johansson; Diabetes - klinisk obesitasforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Insulin resistance; Obesity; Adipose tissue; Adiponutrin; PNPLA; PPARGC1A; Gene expression; Case-control association study; Microarray; Genotyping; Population-based study;

    Abstract : Obesity results from an interaction between genetic and environmental factors and is a growing health problem associated with development of insulin resistance, type 2 diabetes and cardiovascular disease. This thesis has focused on investigating the genetic contribution in obesity and insulin resistance by both candidate and global gene approaches with focus on the adipose tissue. READ MORE