Search for dissertations about: "Genetic Heterogeneity"
Showing result 1 - 5 of 211 swedish dissertations containing the words Genetic Heterogeneity.
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1. Breast cancer : Multifocality, heterogeneity, and related genetic signatures
Abstract : Breast carcinoma often exhibits a complex subgross morphology and may occupy a large volume of the breast tissue and show unifocal, multifocal or diffuse growth patterns. Expression of estrogen- and progesterone receptors, HER2 overexpression, tumor grade, and proliferative activity allows us to classify breast carcinoma into molecular subgroups (Luminal A, Luminal B, HER2-type, triple negative, and basal-like). READ MORE
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2. The Role of Melanocyte Lineage Genes in Melanoma
Abstract : Malignant melanoma accounts for the highest number of deaths among all skin cancer types, and its incidence has increased dramatically over the past decades. Despite the tremendous therapeutic advances, treatment resistant cells emerge in the vast heterogeneity of melanoma, driving tumor relapse and poor patient outcome. READ MORE
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3. Genetic Heteroscedasticity for Domestic Animal Traits
Abstract : Animal traits differ not only in mean, but also in variation around the mean. For instance, one sire’s daughter group may be very homogeneous, while another sire’s daughters are much more heterogeneous in performance. The difference in residual variance can partially be explained by genetic differences. READ MORE
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4. Ethnic heterogeneity of the North-Swedish population : its origin and medical consequences
Abstract : Northern Sweden shows a unique population structure with remarkable geographical variations in the distribution of genetic disorders as well as genetic markers like blood groups, serum groups and red cell enzyme types. The present-day population of northern Sweden is a mixture of people of Finnish, Saamish (Lappish) and Central-Swedish origin. READ MORE
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5. Genetic Risk Factors for Systemic Lupus Erythematosus : From Candidate Genes to Functional Variants
Abstract : The aim of this thesis has been to identify genetic variants that increase the susceptibility for Systemic Lupus Erythematosus (SLE), an autoimmune disease caused by a complex interplay between various genetic and environmental factors. Five different candidate genes were selected through different strategies, and were analysed for association with SLE in an attempt to distinguish some of the underlying mechanisms of this disease. READ MORE