Search for dissertations about: "Genetic polymorphism"

Showing result 1 - 5 of 411 swedish dissertations containing the words Genetic polymorphism.

  1. 1. Genetic Determinants of Dyslipidemia

    University dissertation from Lund University: Faculty of Medicine

    Author : Tibor V Varga; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetic epidemiology; Genetic polymorphism; dyslipidaemia; Cholesterol; Triglyceride; Genetic risk; genetic risk score; Single nucleotide polymorphism; Prediction; Gene-environment interactions; Randomized controlled trial; prospective cohort studies; Observational study; GLACIER Study; Diabetes Prevention Program;

    Abstract : Dyslipidemia is a chronic deviation from normal blood lipid levels that can lead to atherosclerosis and other cardiovascular diseases; dyslipidemia and its sequelae are caused by the complex interplay of genetic and environmental factors. Although circulating concentrations of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (LDL-C) have a strong genetic underpinning, not much is known about the genetic factors that affect long-term deteriorations in lipid concentrations. READ MORE

  2. 2. Male Subfertility and Prostate Cancer Risk: Epidemiological and Genetic Studies

    University dissertation from Lund University: Faculty of Medicine

    Author : Yasir Ruhayel; [2012]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cytoplasmic and nuclear; Receptors; Prostatic neoplasms; genetic; Polymorphism; male; Infertility; Hypogonadism; Genetic association studies; Case–control studies; Androgens;

    Abstract : Androgen action plays a pivotal role in male reproductive tract physiology and pathology. The androgen receptor (AR) gene harbors two codon repeat tracts: the CAG and GGN repeats, encoding corresponding amino acid sequences of variable length; the polyglutamine and polyglycine stretches, respectively. READ MORE

  3. 3. On certain genetic and metabolic risk factors for carotid stenosis and stroke

    University dissertation from Institutionen för medicin och vård

    Author : Pär W. Wanby; Lars Brudin; Martin Carlsson; Milita Crisby; [2006]
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Carotid artery diseases; Carrier proteins; genetics; Cerebrovascular accident; Cerebrovascular disorders; Genetic predisposition to disease; Polymorphism; genetic; VETERINARY MEDICINE Medicine; VETERINÄRMEDICIN Medicin;

    Abstract : The present study evaluated genetic and metabolic factors influencing the risk of acute cerebrovascular disease (CVD) and internal carotid artery stenosis (ICA stenosis) in a Swedish community. The threonine (T) containing protein of the FABP2 A54T gene polymorphism has a greater affinity for long chain fatty acids (FFAs) than the alanine (A) containing protein. READ MORE

  4. 4. THE ANDROGEN RECEPTOR GGN POLYMORPHISM. Genetic and functional analyses

    University dissertation from Department of Clinical Sciences, Lund University

    Author : Kristina Lundin; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine human and vertebrates ; Functional domain; Genetic predisposition; Reproductive function; Sex hormone; Transactivation function; Repeat; Polymorphism; Androgen receptor; Transcription factor; Medicin människa och djur ; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

    Abstract : Male sex development and reproductive function is regulated by androgens acting via the androgen receptor (AR). The AR harbours two polymorphic repeats of CAG and GGN triplets, encoding glutamines and glycines, respectively. READ MORE

  5. 5. Genetic aspects of stroke association and linkage studies in a northern Swedish population

    University dissertation from Umeå : Folkhälsa och klinisk medicin

    Author : Per-Gunnar Wiklund; Birgitta Stegmayr; Kjell Asplund; Dan Holmberg; Alun Evans; [2005]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Internal medicine; stroke; genetics; polymorphism; association; linkage; risk factors; plasminogen activator inhibitor-1; tissue plasminogen activator; angiotensin converting enzyme; angiotensin II receptor type 1; phosphodiesterase 4D; Invärtesmedicin; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Internal medicine; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Invärtesmedicin; medicin; Medicine;

    Abstract : Stroke is a common, multifactorial cardiovascular disease. A stroke event is the result of traditional risk factors (i.e. hypertension, diabetes, smoking), environmental exposures and genetic factors in a complex interplay. READ MORE