Search for dissertations about: "Genetic predisposition to disease"

Showing result 1 - 5 of 102 swedish dissertations containing the words Genetic predisposition to disease.

2. 1. Genetic Predisposition to Sporadic and Familial Multiple Myeloma

   Author : Britt-Marie Halvarsson; Avdelningen för hematologi och transfusionsmedicin; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; multiple myeloma; genetics; inherited predisposition; familial multiple myeloma; GWAS; polygenic risk score;

   Abstract : Multiple Myeloma (MM) is the second most common hematological malignancy. It is defined by an uncontrolled growth of plasma cells, usually in the bone marrow. Clinically it is complicated by hypercalcemia, renal failure, anaemia, and bone pain. READ MORE

4. 2. Genetic predisposition to salt sensitivity and cardiovascular disease

   Author : Jonas Dahlberg; Kardiovaskulär forskning - hypertoni; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NEDD4L; SGK-1; CVD; ischemic stroke; genetics; CVD deaths; myopcardial infarction;

   Abstract : Abstract The average amount of salt ingested is about 10 grams daily compared to less than one gram in pre-historic life. Salt, althought somewhat debated, is considered a risk factor for elevated blood pressure and end organ damage beyond the blood pressure effect. READ MORE

5. 3. On certain genetic and metabolic risk factors for carotid stenosis and stroke

   Author : Pär Wanby; Lars Brudin; Martin Carlsson; Milita Crisby; Linköpings universitet; []
   Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Carotid artery diseases; Carrier proteins; genetics; Cerebrovascular accident; Cerebrovascular disorders; Genetic predisposition to disease; Polymorphism; genetic; Medicine; Medicin; Medicin;

   Abstract : The present study evaluated genetic and metabolic factors influencing the risk of acute cerebrovascular disease (CVD) and internal carotid artery stenosis (ICA stenosis) in a Swedish community. The threonine (T) containing protein of the FABP2 A54T gene polymorphism has a greater affinity for long chain fatty acids (FFAs) than the alanine (A) containing protein. READ MORE

6. 4. Genetic Studies of Rheumatoid Arthritis using Animal Models

   Author : Niklas Nordquist; William Dietrich; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Complex disease; autoimmune; rheumatoid arthritis; genetic; mapping; QTL; locus; linkage; animal model; rat; Genetik; Clinical genetics; Klinisk genetik; Medical Genetics; medicinsk genetik;

   Abstract : Predisposition to autoimmune diseases such as, rheumatoid arthritis, diabetes, and multiple sclerosis, is caused by the effect of multiple genes and a strong influence from the environment. In this study, I have investigated genetic factors that confer susceptibility to rheumatoid arthritis in a rat model. READ MORE

7. 5. On the aetiology of ALS : a comprehensive genetic study

   Author : Caroline Ingre; Peter M Andersen; Rayomand Press; Siddharthan Chandran; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALS; risk factor; VAPB; SOD1; amyotrophic lateral sclerosis; ATXN2; SMN1; SMN2; PFN1; 50 bp deletion in SOD1 promotor; population-specific genetic variations; Neurology; neurologi;

   Abstract : Introduction: Amyotrophic lateral sclerosis (ALS) is a deadly, progressive neuromuscular disease that affects individuals all over the world. About 10% of the patients have a familial predisposition (FALS) while the remainder of cases are isolated or sporadic (SALS) and of unknown cause. READ MORE