Search for dissertations about: "Genetic screens"

Showing result 1 - 5 of 36 swedish dissertations containing the words Genetic screens.

  1. 1. Zebrafish models for large-scale genetic screens in dyslipidemia and atherosclerosis : Validation and application

    Author : Manoj Kumar Bandaru; Marcel den Hoed; Anastasia Emmanouilidou; Ingelsson Erik; Shannon Fisher; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; zebrafish; dyslipidemia; atherosclerosis; genetic screens; high-cholesterol diet; APOE; APOB; LDLR; APOC2; PCSK9; LPAR2; GATAD2A; Medicinsk genetik; Medical Genetics;

    Abstract : Hundreds of loci have been robustly associated with circulating lipids, atherosclerosis and coronary artery disease; but for most loci the causal genes and mechanisms remain uncharacterized. The overall aim of my thesis is to develop and validate novel in vivo model systems that are suitable for high-throughput, image-based genetic screens in coronary artery disease and related traits, and use these model systems to systematically characterize positional candidate genes. READ MORE

  2. 2. Identification of intrinsic regulators in normal and malignant human hematopoiesis. An RNA-interference approach

    Author : Roman Galeev; Avdelningen för molekylärmedicin och genterapi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hematopoietic stem cell; RNA interference; Acute myeloid leukemia; myelodysplastic syndrome; genetic screens; next generation sequencing; genetic regulators;

    Abstract : Bildandet av blodceller, hematopoesen, utgår från ett litet antal av de så kallade hematopoetiska stamceller som sitter i vår benmärg. Dessa celler har förmågan att ge upphov till alla mogna blodcellstyper av de tre hematopoetiska linjerna, samtidigt som de genom celldelning bibehåller sin egna mängd. READ MORE

  3. 3. From GWAS to gene : Zebrafish as a model system for large-scale studies of obesity and comorbidities

    Author : Eugenia Mazzaferro; Marcel den Hoed; Randall Peterson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; zebrafish; genetic screens; gene editing; CRISPR Cas9; obesity; Medicinsk genetik; Medical Genetics;

    Abstract : Obesity increases the risk of developing comorbidities such as cardiovascular and metabolic diseases. However, not all obese individuals develop comorbidities, and those that do not are referred to as “metabolically healthy obesity” individuals. READ MORE

  4. 4. Activation of the Cellular Immune Response in Drosophila melanogaster Larvae

    Author : Ines Anderl; Dan Hultmark; Paul Badenhorst; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Drosophila melanogaster; immunity; blood cells; hematopoiesis; flow cytometry; in vivo imaging; genetic screens; Tl10b; fat body; Toll signaling; molekylärbiologi; Molecular Biology;

    Abstract : During the last 40 years, Drosophila melanogaster has become an invaluable tool in understanding innate immunity. The innate immune system of Drosophila consists of a humoral and a cellular component. While many details are known about the humoral immune system, our knowledge about the cellular immune system is comparatively small. READ MORE

  5. 5. Genetic mapping and association analysis in multiple sclerosis

    Author : Eva Åkesson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Multiple sclerosis; genetic; linkage; association; susceptibility;

    Abstract : Multiple sclerosis (MS) is a chronic neurological disease. Epidemiological studies have shown evidence for both environmental and genetic involvement of the disease. READ MORE