Search for dissertations about: "Genetic-Code"

Showing result 1 - 5 of 32 swedish dissertations containing the word Genetic-Code.

  2. 1. Inference of Hierarchical Structure in Complex Systems

    Author : Olof Görnerup; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Protein evolution; Substitution groups; Modularity; Hierarchical dynamics; RNA world; Genetic code; Aggregation; Primordial evolution; Molecular evolution; Model reduction; Self-organization; Lumping; Emergence; Coarse graining;

    Abstract : Hierarchical organization is a central property of complex systems. It is even argued that a system is required to be hierarchical in order to evolve complexity within reasonable time. A hierarchy of a system is defined as the set of self-contained levels at which the system operates and can be described on. READ MORE

  4. 2. Accuracy of mRNA Translation in Bacterial Protein Synthesis

    Author : Jingji Zhang; Måns Ehrenberg; Olke C. Uhlenbeck; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; protein synthesis; genetic code; misreading; error hot spots; kinetics; aminoglycoside; Biokemi; Biochemistry;

    Abstract : Reading of messenger RNA (mRNA) by aminoacyl-tRNAs (aa-tRNAs) on the ribosomes in the bacterial cell occurs with high accuracy. It follows from the physical chemistry of enzymatic reactions that there must be a trade-off between rate and accuracy of initial tRNA selection in protein synthesis: when the current accuracy, the A-value, approaches its maximal possible value, the d-value, the kinetic efficiency of the reaction approaches zero. READ MORE

  5. 3. Genetic code expansion in neurons for studying pathogenic mechanisms of Alzheimer disease

    Author : Lea Susanne van Husen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Every three seconds a new patient is diagnosed with Alzheimer disease (AD). The primary risk factor for this irreversible, progressive brain disorder is old age. It is a growing health concern, not only for the patients, but also for their relatives and society, because the number of affected people is expected to double every 20 years. READ MORE

  6. 4. Stretching the genetic code : incorporation of selenocysteine at specific UGA codons in recombinant proteins produced in Escherichia coli

    Author : Olle Rengby; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Selenocysteine (Sec) exists in all domains of life and represents the 21st naturally occurring amino acid. A Sec residue is co-translationally incorporated at a predefined opal (UGA) codon. UGA codons normally encode for translational stop via the protein release factor 2 (RF2). READ MORE

  7. 5. Determination of transcription factor binding specificities

    Author : Arttu Jolma; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The term "genetic code" refers to the way in which the information encoded in nucleic acids is converted into the amino-acid sequence of proteins. There is however also a second genetic code, one that is used by the cells to read the blueprints of the entire organism. READ MORE