Search for dissertations about: "Genome wide associations study GWAS"

Showing result 1 - 5 of 25 swedish dissertations containing the words Genome wide associations study GWAS.

  2. 1. Genetics of complex disease

    Author : Viktor Henmyr; Molekylär cellbiologi; []
    Keywords : complex disease; allergic rhinitis; Chronic rhinosinusitis; genetics; associations; GWAS; resequencing;

    Abstract : To find true genetic associations in complex diseases, such as allergic rhinitis and chronic rhinosinusitis, is a difficult task. Both are polygenetic diseases where it is believed that genetic variation in several genes make up their phenotypes. READ MORE

  4. 2. The effect of common and rare variants on inflammatory traits and diseases

    Author : Julia Höglund; Åsa Johansson; Matthew Robinson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GWAS; inflammation; biomarkers; WES; WGS; NSPHS; UK Biobank; association study;

    Abstract : Genome wide association studies (GWAS) have identified thousands of loci associated to an immense number of traits and diseases. Most associations have been to common variants, but rare variant associations are progressively being reported. READ MORE

  5. 3. Using systems genetics to explore the complexity of leaf shape variation in Populus tremula

    Author : Barbara Terebieniec; Nathaniel Street; Chung-Jui Tsai; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Populus; Arabidopsis; systems biology; systems genetics; spatial transcriptomics ST ; single nucleotide polymorphism SNP ; Genome wide associations study GWAS ; expression GWAS eGWAS ; molekylärbiologi; Molecular Biology;

    Abstract : Leaves are essential for sustaining humanity as they function as the energy and oxygen-producing organ of plants. Intensive research on physiological processes has contributed immensely to our understanding of the function of leaves. However, comparatively little is known about how leaf size and shape is determined. READ MORE

  6. 4. Novel statistical methods for genome-wide association summary statistics

    Author : Zheng Ning; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : A general objective of genetic studies is to understand the genetic basis of complex traits such as height, body mass index (BMI), disease endpoints, etc. Such researches have been facilitated due to the completion of the human genome project and developments of high-throughput technologies. READ MORE

  7. 5. Genetic factors affecting pregnancy duration in humans

    Author : Jonas Bacelis; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; genomics; GWAS; Mendelian randomization; causal inference; preterm birth; pregnancy; gestation; height; text mining;

    Abstract : This thesis investigates the mechanisms behind human pregnancy duration. Too short gestation is a direct cause of perinatal, neonatal, and infant mortality. Deviation from normal pregnancy length is also associated with a child's morbidity, even in the adulthood. READ MORE