Search for dissertations about: "Genome-wide gene regulation"
Showing result 1 - 5 of 118 swedish dissertations containing the words Genome-wide gene regulation.
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1. Genome-Wide Studies of Transcriptional Regulation in Mammalian Cells
Abstract : The key to the complexity of higher organisms lies not in the number of protein coding genes they carry, but rather in the intrinsic complexity of the gene regulatory networks. The major effectors of transcriptional regulation are proteins called transcription factors, and in this thesis four papers describing genome-wide studies of seven such factors are presented, together with studies on components of the chromatin and transcriptome. READ MORE
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2. Aneuploidy compensatory mechanisms and genome-wide regulation of gene expression in Drosophila melanogaster
Abstract : Stimulation or repression of gene expression by genome-wide regulatory mechanisms is an important epigenetic regulatory function which can act to efficiently regulate larger regions or specific groups of genes, for example by compensating for loss or gain of chromosome copy numbers. In Drosophila melanogaster there are two known chromosome-wide regulatory systems; the MSL complex, which mediates dosage compensation of the single male X-chromosome and POF, which stimulates expression from the heterochromatic 4th chromosome. READ MORE
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3. Genome-Wide Studies of Transcriptional Regulation in Human Liver Cells by High-throughput Sequencing
Abstract : The human genome contains slightly more than 20 000 genes that are expressed in a tissue specific manner. Transcription factors play a key role in gene regulation. By mapping the transcription factor binding sites genome-wide we can understand their role in different biological processes. READ MORE
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4. RNA-based mechanisms of chromatin and gene regulation
Abstract : Cells regulate gene expression in a particular spatio-temporal manner by executing specific transcriptional programs. The different transcriptional programs allow the generation of the different cell types in multicellular organisms and mediate particular cellular responses to external cues such as viral infections. READ MORE
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5. Signals and Noise in Complex Biological Systems
Abstract : In every living cell, millions of different types of molecules constantly interact and react chemically in a complex system that can adapt to fluctuating environments and extreme conditions, living to survive and reproduce itself. The information required to produce these components is stored in the genome, which is copied in each cell division and transferred and mixed with another genome from parent to child. READ MORE
