Search for dissertations about: "Genome-wide"
Showing result 1 - 5 of 522 swedish dissertations containing the word Genome-wide.
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1. Genome-Wide Studies of Transcriptional Regulation in Mammalian Cells
Abstract : The key to the complexity of higher organisms lies not in the number of protein coding genes they carry, but rather in the intrinsic complexity of the gene regulatory networks. The major effectors of transcriptional regulation are proteins called transcription factors, and in this thesis four papers describing genome-wide studies of seven such factors are presented, together with studies on components of the chromatin and transcriptome. READ MORE
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2. Statistical Methods for Genome Wide Association Studies
Abstract : This thesis focus on various statistical methods for analyzing Genome Wide Association data. The thesis include four papers, three of them considers the analysis of complex traits, and the last one a method for analyzing mendelian traits. READ MORE
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3. Genome-Wide Studies of Transcriptional Regulation in Human Liver Cells by High-throughput Sequencing
Abstract : The human genome contains slightly more than 20 000 genes that are expressed in a tissue specific manner. Transcription factors play a key role in gene regulation. By mapping the transcription factor binding sites genome-wide we can understand their role in different biological processes. READ MORE
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4. Improving methods for Genome Wide Analysis of Coeliac Disease
Abstract : .... READ MORE
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5. Genetic Analyses of Multiple Sclerosis and Systemic Lupus Erythematosus : From Single Markers to Genome-Wide Data
Abstract : In autoimmune diseases an individual’s immune system becomes targeted at the body’s own healthy cells. The aim of this thesis was to identify genetic risk factors for the two autoimmune diseases multiple sclerosis (MS) and systemic lupus erythematosus (SLE). READ MORE