Search for dissertations about: "Genomes"

Showing result 1 - 5 of 392 swedish dissertations containing the word Genomes.

  2. 1. Methods for Analyzing Genomes

    Author : Patrik L. Ståhl; Joakim Lundeberg; Ivo Gut; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; array; sequence capture; genotyping; trinucleotide threading; sequencing; massively parallel sequencing; single molecule sequencing; Visual DNA; p53; single nucleotide polymorphism; biomarker; Genetics; Genetik;

    Abstract : The human genome reference sequence has given us a two‐dimensional blueprint of our inherited code of life, but we need to employ modern‐day technology to expand our knowledge into a third dimension. Inter‐individual and intra‐individual variation has been shown to be larger than anticipated, and the mode of genetic regulation more complex. READ MORE

  4. 2. Divergence, admixture and continuity in the human past : Demographic inference using ancient and modern genomes

    Author : James McKenna; Mattias Jakobsson; Per Sjödin; Ida Moltke; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Human evolution; population genetics; ancient genomes; population continuity; divergence; Biology with Specialisation in Human Evolution and Genetics; Biologi med inriktning mot människans evolution och genetik;

    Abstract : Demographic forces shaping the genetic variation we observe today can include population divergences, admixture events and continuity through time. The advancement of high-throughput sequencing technologies, together with developments in molecular and bio-informatics methods, mean the number of ancient genomes available for inference has risen steeply. READ MORE

  5. 3. Rates and patterns of molecular evolution in avian genomes

    Author : Paulina Bolívar; Hans Ellegren; Carina F. Mugal; Mikkel Heide Schierup; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Molecular evolution; recombination; GC-biased gene conversion; Hill-Robertson interference; effective population size; dN dS; distribution of fitness effects; avian genomes; collared flycatcher; sex chromosomes; Biology with specialization in Evolutionary Genetics; Biologi med inriktning mot evolutionär genetik;

    Abstract : Evolution is the change in inherited characteristics of a population through subsequent generations. The interplay of several evolutionary mechanisms determines the rate at which this change occurs. READ MORE

  6. 4. Neurospora tetrasperma from Natural Populations : Toward the Population Genomics of a Model Fungus

    Author : Pádraic Corcoran; Hanna Johannesson; Sylvain Glemin; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Neurospora; poulation genetics; genomes; introgression; Evolutionary Genetics; Evolutionär genetik;

    Abstract : The study of DNA sequence variation is a powerful approach to study genome evolution, and to reconstruct evolutionary histories of species. In this thesis, I have studied genetic variation in the fungus Neurospora tetrasperma and other closely related Neurospora species. I have focused on N. READ MORE

  7. 5. Computational exploration of cancer genomes

    Author : Joakim Karlsson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Cancer genomics; Transcriptomics; Driver genes; Copy number changes; Immunogenomics; Cancer of unknown primary; Uveal melanoma;

    Abstract : Cancer evolves due to changes in DNA that give a cell an advantage at the expense of the remaining organism. These alterations range from individual base substitutions to broad losses or duplications of chromosomal material. READ MORE