Search for dissertations about: "Gentranskription"

Found 5 swedish dissertations containing the word Gentranskription.

  2. 1. Transcriptional biomarkers of toxicity – powerful tools or random noise? : An applied perspective from studies on bivalves

    Author : Gustaf Magnus Oskar Ekelund Ugge; Olof Berglund; Annie Jonsson; Helena Westerdahl; Mikael Ejdebäck; Bruno Nunes; Högskolan i Skövde; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Biomarkers; Bivalves; Bivalvia; Ecotoxicology; Environmental toxicology; Environmental risk assessment; RT-qPCR; qPCR; Quantitative PCR; Systematic review; Meta-analysis; Dose-response relationships; Concentration-response relationships; Heavy metals; Metals; General toxicity; Copper; Duck mussel; Anodonta anatina; Freshwater; Gene transcription; Biomarkörer; Musslor; Bivalvia; Ekotoxikologi; Miljötoxikologi; Miljöriskbedömning; RT-qPCR; qPCR; Kvantitativ PCR; Systematic review; Metaanalys; Dos-responssamband; Koncentration-responssamband; Tungmetaller; Metaller; Allmän toxicitet; Koppar; Allmän dammussla; Anodonta anatina; Sötvatten; Gentranskription; Ekologisk modellering; Ecological Modelling Group; Biomarkörer; Musslor; Bivalvia; Ekotoxikologi; Miljötoxikologi; Miljöriskbedömning; RT-qPCR; qPCR; Kvantitativ PCR; Systematic review; Metaanalys; Dos-responssamband; Koncentration-responssamband; Tungmetaller; Metaller; Allmän toxicitet; Koppar; Allmän dammussla; Anodonta anatina; Sötvaten; Gentranskription; Biomarkers; Bivalves; Ecotoxicology; Environmental toxicology; Environmental risk assessment; Quantitative PCR; Meta-analysis; Dose-response relationships; Concentration-response relationships; Heavy metals; Metals; General toxicity; Copper; Duck mussel; Freshwater; Gene transcription;

    Abstract : Aquatic organisms are constantly at risk of being exposed to potentially harmful chemical compounds of natural or anthropogenic origin. Biological life can for instance respond to chemical stressors by changes in gene expression, and thus, certain gene transcripts can potentially function as biomarkers, i.e. READ MORE

  4. 2. G protein-coupled estrogen receptor 1 (GPER) in the female reproductive tract: from physiology to cancer

    Author : Zuzana Kolkova; Lund Obstetrik och gynekologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Estrogen effects are mediated either through genomic action involving the classical estrogen receptors, estrogen receptor alpha (ERα) and beta (ERß), which function as transcription factors in the nucleus, or through rapid non-genomic action via receptors associated with plasma membrane. Recently, a member of the G protein-coupled receptor family was ascribed estrogen receptor properties and proposed as a candidate for mediating non-genomic estrogen signaling. READ MORE

  5. 3. Transcription regulation across levels of chromatin organization

    Author : Roshan Vaid; Mattias Mannervik; Goncalo Castelo-Branco; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transcription; chromatin; epigenetics; Drosophila; embryo development; molekylär biovetenskap; Molecular Bioscience;

    Abstract : With advancements in high-throughput sequencing and high-resolution microscopy techniques, the significance of genome organization in transcription regulation is rapidly unveiling. Nonetheless, we are yet far from completely understanding this key relationship. READ MORE

  6. 4. Molecular Mechanism of Growth Hormone - Involvement of Janus Kinase 2, Insulin Receptor Substrate-1 and -2 and Phosphatidylinositol 3-Kinase In the Acute Insulin-Like Effects of Growth Hormone In Primary Rat Adipocytes

    Author : Martin Ridderstråle; Diabetes - klinisk obesitasforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; insulin receptor substrate-1; insulin receptor substrate-2 phosphatidylinositol 3-kinase; signal transducer and activator of transcription 5; janus kinase 2; phosphotyrosine; receptor; phosphorylation; Growth hormone; Metabolism; Biochemistry; rat; adipocyte; lipolysis; lipogenesis; Biokemi; metabolism; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

    Abstract : Originally studying the molecular mechanisms for the insulin-like effects of growth hormone (GH), lipogenesis and antilipolysis, in isolated rat adipocytes we found that the GH receptor (GHR) was tyrosine phosphorylated in response to GH in cells that were responsive to these effects. Then, as Janus kinase 2 (JAK2) was described as a GH-stimulated and GHR-associated tyrosine kinase, we found that JAK2 was tyrosine phosphorylated in response to GH in responsive cells. READ MORE

  7. 5. Signaling and Adhesive Mechanisms in Acute Pancreatitis

    Author : Darbaz Awla; Kirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; trypsinogen activation; Acute pancreatitis; leukocyte recruitment and adhesion;

    Abstract : Acute pancreatitis (AP) is an inflammatory disease with variable severity ranging from mild interstitial edematous to severe necrotizing disease. The overall mortality rate of AP is 8-9%. Specific treatment of AP is lacking which is partly related to an incomplete understanding of the basic pathophysiology behind the disease. READ MORE