Search for dissertations about: "Germinal centres"

Found 5 swedish dissertations containing the words Germinal centres.

2. 1. Signalling mechanisms in B cell differentiation: Studies on specific human immune response in vitro

   Author : Sigurdur Ingvarsson; Institutionen för immunteknologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; Bioteknik; Biotechnology; CD44; CD40; Specific antibody secretion; B cells; Germinal centres; serology; transplantation; Immunologi; serologi;

   Abstract : We need to understand the major signalling events in human B cell differentiation in order to be able to regulate the generation of human antigen specific antibodies. This study has focused on the signalling mechanisms involved in generation of germinal centre reaction and secretion of specific antibodies by human B cells, using different in vitro immunisation technologies. READ MORE

4. 2. The Germinal Centre reaction - Genetic and proteomic analysis of factors important for survival and growth of B lymphocytes

   Author : Linda Zander; Göteborgs universitet; []
   Keywords : B lymphocyte; germinal centre; transformation; serum-free; MHC class II; bare lymphocyte syndrome; extracellular proteins; DNA repair; Polymerase ?;

   Abstract : During an immune response the B lymphocytes main function is to produce antibodies in the specific defence against the pathogen. When naïve B lymphocytes become activated by binding of an antigen, the cells differentiate to become antibody producing plasma cells. READ MORE

5. 3. Cellular and Molecular Aspects of the Germinal Centre Reaction

   Author : Katarina Dahlenborg; Institutionen för immunteknologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; serology; Immunology; Biotechnology; Bioteknik; transplantation; Immunologi; serologi;

   Abstract : The humoral immune response to a T cell dependent protein antigen will over time generate antibodies with an increased affinity to the antigen. This is due to a process known as affinity maturation and proceeds in a, for this purpose, well designed micro-milieu within secondary lymphoid organs known as germinal centres. READ MORE

6. 4. B cell activation in vitro: thymus-dependent immune responses and bacterial cell surface proteins

   Author : Karol Axcrona; Immunologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nuclear transport; bacterial Ig-binding proteins; CD40L promoter; CD21; Ig; B lymphocyte activation in vitro; CD40; Immunology; serology; transplantation; Immunologi; serologi;

   Abstract : In this thesis aspects of peripheral B lymphocyte differentiation were studied. Through in vitro experiments, B lymphocyte activation was assessed. B lymphocytes express immunoglobulin (Ig) specific for a certain antigen on the cell surface, and when surface Ig is crosslinked by an antigen, the cell is activated. READ MORE

7. 5. The CD40 Receptor - Target,Tool and Technology

   Author : Peter Ellmark; Institutionen för immunteknologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; serology; transplantation; Immunologi; serologi; SPIRE; mammalian; library; cDNA; selection; receptor revision; phage display; scFv; human; CD40; antibodies;

   Abstract : CD40 is a cell surface receptor of pivotal importance that is expressed on several of the cells in the immune system. It is critical for many important events, such as T cell dependent B cell activation, isotype switching, somatic mutation and generation of B cell memory. READ MORE