Search for dissertations about: "Germinal"
Showing result 1 - 5 of 93 swedish dissertations containing the word Germinal.
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1. Regulation of the germinal center response by T follicular helper cells and type I interferons
Abstract : The protective effect of most currently available vaccines is dependent on high-affinity antibodies and long lived B cell memory, which develop within organized structures of secondary lymphoid organs called germinal centers (GCs). GC formation is supported by T follicular helper (Tfh) cells, a subset of CD4+ T cells that develop in parallel to other effector T cells and specifically localizes to B cell follicles. READ MORE
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2. The Germinal Centre reaction - Genetic and proteomic analysis of factors important for survival and growth of B lymphocytes
Abstract : During an immune response the B lymphocytes main function is to produce antibodies in the specific defence against the pathogen. When naïve B lymphocytes become activated by binding of an antigen, the cells differentiate to become antibody producing plasma cells. READ MORE
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3. Cellular and Molecular Aspects of the Germinal Centre Reaction
Abstract : The humoral immune response to a T cell dependent protein antigen will over time generate antibodies with an increased affinity to the antigen. This is due to a process known as affinity maturation and proceeds in a, for this purpose, well designed micro-milieu within secondary lymphoid organs known as germinal centres. READ MORE
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4. Signalling mechanisms in B cell differentiation: Studies on specific human immune response in vitro
Abstract : We need to understand the major signalling events in human B cell differentiation in order to be able to regulate the generation of human antigen specific antibodies. This study has focused on the signalling mechanisms involved in generation of germinal centre reaction and secretion of specific antibodies by human B cells, using different in vitro immunisation technologies. READ MORE
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5. Studies of T- and B-cells for the generation of human antigen specific antibodies
Abstract : Human antibodies generated in vitro may be highly valuable for diagnostic and therapeutic purposes. For a long time most human antibodies produced in vitro have been of the IgM isotype with rather low affinities. In this thesis a method for production of IgG switched antigen-specific human antibodies is presented. READ MORE