Search for dissertations about: "Glioblastoma Multiforme GBM"

Showing result 1 - 5 of 27 swedish dissertations containing the words Glioblastoma Multiforme GBM.

2. 1. Modeling glioblastoma heterogeneity to decipher its biology

   Author : Yuan Xie; Lene Uhrbom; Massimo Squatrito; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioblastoma multiforme; biobank; GBM cells; cell of origin; LGR5; OPCs;

   Abstract : Glioblastoma multiforme (GBM) is the most common and lethal form of primary brain tumor that mainly affects adults. GBM displays remarkable intra- and inter-tumoral heterogeneity and contains a subpopulation of cells named glioma stem cells that is believed to be responsible for tumor maintenance, progression and recurrence. READ MORE

4. 2. Glioblastoma multiforme in the microscope: Diagnostic features of importance for prognosis and treatment

   Author : Annette Persson; Tumörmikromiljö; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; General pathology; cytogenetik; Genetik; Genetics; cytogenetics; Medicin människa och djur ; macrophages; adenoviral based gene-therapy proliferation activity; telomerase activity; immunohistochemistry; Medicine human and vertebrates ; cytotoxic T-lymphocytes; diagnostic features; prognosis; immuno-therapy; Glioblastoma multiforme; neuropathology; pathological anatomy; Patologi allmän ; patologisk anatomi;

   Abstract : Glioblastoma multiforme (GBM) is the most malignant and also the most common form of brain tumour in humans. The overall aim of this thesis was to investigate morphological and diagnostics features in human GBM that may be of importance for prognosis and treatment. READ MORE

5. 3. Glioma as an Ecosystem : Studies of Invasion, Onco-miR Addiction and Mast Cell Infiltration

   Author : Jelena Põlajeva; Bengt Westermark; Ingemar Ernberg; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glioblastoma; mast cell; miR-21; RAP1; CXCL12; SOX2;

   Abstract : Despite recent advances in oncology and extensive research efforts, gliomas remain essentially incurable. Glioblastoma multiforme (GBM, WHO grade IV) is the most common glioma and may arise de novo or progress from a lower-grade lesion. GBM is characterized by invasive growth, aberrant angiogenesis and necrosis. READ MORE

6. 4. Exploitation of interactions with the neonatal Fc receptor to manipulate biological half-lives for therapeutic applications

   Author : Shengze Yu; Torbjörn Gräslund; Mats Ohlin; KTH; []
   Keywords : Glioblastoma Multiforme GBM ; Prolacin Prl ; Prolacin receptor PrlR ; Prolactin antagonist PrlRA ; Albumin binding domain ABD ; serum albumin SA ; half-life extension; FcRn; Affibody; human growth hormone hGH ; immunoglobulin G IgG ; blocking; autoimmune disease; Bioteknologi; Biotechnology;

   Abstract : Protein engineering provides powerful tools to create useful proteins with desired properties. In this thesis, rational design principles have been used for development of fusion proteins that can interact with the neonatal Fc receptor (FcRn) for potential medical applications. FcRn is widely expressed in the human body. READ MORE

7. 5. Gene expression studies in human astrocytoma, with emphasis on oncostatin M induced effects

   Author : Annika Krona; Göteborgs universitet; []
   Keywords : Brain tumors; astrocytoma; glioblastoma multiforme; oncostatin M OSM ; STAT; microarray;

   Abstract : Brain tumors comprise about one percent of all cancers and astrocytoma is the most common primary brain malignancy. According to the World Health Organization system, the astrocytomas are divided into four grades according to degree of malignancy. Grade I, pilocytic astrocytoma (PA), is the least malignant form and most often affects children. READ MORE