Search for dissertations about: "Glucose homeostasis"
Showing result 1 - 5 of 209 swedish dissertations containing the words Glucose homeostasis.
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1. Pharmacometrics Modelling in Type 2 Diabetes Mellitus : Implications on Study Design and Diabetes Disease Progression
Abstract : Pharmacometric modelling is widely used in many aspects related to type 2 diabetes mellitus (T2DM), for instance in the anti-diabetes drug development, and in quantifying the disease progression of T2DM.The aim of this thesis were to improve the design of early phase anti-diabetes drug development studies with the focus on the power to identify mechanism of drug action (MoA), and to characterize and quantify the progression from prediabetes to overt diabetes, both the natural progression and the progression with diet and exercise interventions, using pharmacometrics modelling. READ MORE
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2. Jejunal control of glucose homeostasis in the human body
Abstract : Background: The prevalence of obesity and type-2 diabetes mellitus (T2DM) have risen dramatically over the last decades, and are major threats to the human health. Obesity, and also T2DM, is treated with lifestyle modifications, medications or by bariatric surgery, with varying success. READ MORE
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3. Mechanism-Based Modelling of Clinical and Preclinical Studies of Glucose Homeostasis
Abstract : Glucose is an important nutrient and energy source in the body. However, too high concentration in the blood is harmful and may lead to several complications developing over time. It was estimated that 5 million people in the world died from complications related to diabetes during 2015. READ MORE
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4. Pharmacometric Models of Glucose Homeostasis in Healthy Subjects and Diabetes Patients
Abstract : Diabetes is a group of metabolic diseases characterized by hyperglycaemia resulting from defects in insulin secretion, insulin action, or both. Several models have been developed for describing the glucose-insulin system. READ MORE
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5. Studies on factors modulating glucose homeostasis in healthy and diabetic rats
Abstract : Glucose is the most common substrate for energy metabolism. Despite the varying demands for glucose, the body needs to regulate its internal environment and maintain a constant and stable condition. Glucose homeostasis requires harmonized interaction between several tissues, achieving equilibrium between glucose output and uptake. READ MORE