Search for dissertations about: "Glutamic Acid Decarboxylase 65 GAD65"

Showing result 1 - 5 of 10 swedish dissertations containing the words Glutamic Acid Decarboxylase 65 GAD65.

  2. 1. Immunogenetics of Childhood Type 1 Diabetes in Immigrant Patients in Sweden. Migration Studies on Type 1 Diabetes

    Author : Ahmed Delli; Celiaki och diabetes; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diabetes; Type 1 Diabetes; Childhood; Human Leukocyte Antigen HLA ; Islet autoantibodies; Zinc Transporter 8 ZnT8 ; Islet antigen IA2- ; Glutamic Acid Decarboxylase 65 GAD65; Insulin; Migration.;

    Abstract : This thesis examined whether the offspring of immigrants (non-Swedes) to Sweden are at increased risk of Type 1 Diabetes (T1D) when they are born or live in Sweden. It also evaluated if their T1D and T2D-related genes differed from Swedish patients and whether this genetic heritage determined the types and existence of islet autoantibodies at time of diagnosis and affected the classification of diabetes. READ MORE

  4. 2. GAD65 An Immunomodulator in Type 1 Diabetes

    Author : Stina Axelsson; Rosaura Casas; Johnny Ludvigsson; Guro Gafvelin; Linköpings universitet; []
    Keywords : ;

    Abstract : Type 1 diabetes (T1D) is caused by a deficiency of insulin as a result of an autoimmune destruction of the pancreatic ² -cells. A possibility to preserve remaining ² -cells in children with newly diagnosed T1D is of great importance since sustained ² -cell function is recognized to result in reduced end-organ complications. READ MORE

  5. 3. Characteristics of GADA in Type 1 Diabetes following Immunomodulation with GAD65

    Author : Mikael Chéramy; Rosaura Casas; Johnny Ludvigsson; Mona Landin-Olsson; Linköpings universitet; []
    Keywords : ;

    Abstract : Type 1 diabetes (T1D) is a serious autoimmune disease which increases worldwide and affects children at a young age, but there still is no cure available. Clinical intervention trials in recent onset T1D patients are therefore very important, since even a modest preservation of β-cell function has proven to reduce end-organ complications. READ MORE

  6. 4. Organ-specific autoantibodies in Addison's disease and autoimmune polyendocrine syndrome type I

    Author : Annika Söderbergh; Uppsala universitet; []
    Keywords : Medical sciences; Addison s disease; APS I; Down syndrome; AIRE; autoantibodies; autoantigens; autoimmunity; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Abstract : Assessment of autoantibodies is a valuable tool in the diagnostic procedure of autoimmune diseases. The aim of this study was to investigate the prevalence of different autoantibodies and their associations with disease manifestations in patients with Addison's disease and autoimmune polyendocrine syndrome type I (APS I). READ MORE

  7. 5. The Importance of CTLA-4 and HLA Class II for Type 1 Diabetes Immunology

    Author : Carl-Oscar Jonson; Johnny Ludvigsson; Maria Faresjö; Dan Holmberg; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 Diabetes; Genetics; Diabetology; Diabetologi;

    Abstract : Type 1 Diabetes (T1D) is a serious chronic disease that results from an autoimmune destruction of the insulin-producing beta cells. Sweden has the second highest incidence of T1D in the world, and it affects more and more children each year. Genes controlling key functions of the immune system regulation of autoimmunity has been associated to T1D. READ MORE