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Showing result 1 - 5 of 59 swedish dissertations matching the above criteria.

  2. 1. Glutathione transferases : molecular cloning, site-directed mutagenesis and structure-function studies

    Author : Gun Stenberg; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : Three distinct glutathione transferases (GST) cDNA clones were obtained by screening of tumour cell line cDNA libraries. The cDNA clones were expressed in Escherichia coli and the enzymes characterized. Rat GST 8-8 is the only member in the multifunctional GST family for which a specific cellular function has been proposed. READ MORE

  4. 2. Glutathione transferases : studies on the structure and function of recombinant enzymes

    Author : Mikael Widersten; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP;

    Abstract : .... READ MORE

  5. 3. Cytosolic glutathione transferases : inhibition characteristics as new criteria for identification of different isoenzymes and demonstration of class Pi enzymes in normal mammalian tissues and tumor cells

    Author : Muhammad Kalim Tahir; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : .... READ MORE

  6. 4. Cytosolic glutathione transferases : classification and aspects of structure and function

    Author : Per Ålin; Stockholms universitet; []
    Keywords : ;

    Abstract : .... READ MORE

  7. 5. Role of Multiple Glutathione Transferases in Bioactivation of Thiopurine Prodrugs : Studies of Human Soluble Glutathione Transferases from Alpha, Kappa, Mu, Omega, Pi, Theta, and Zeta Classes

    Author : Birgitta I. Eklund; Bengt Mannervik; Mikael Widersten; Ralf Morgenstern; Uppsala universitet; []
    Keywords : Biochemistry; Glutathione Transferases; Thiopurines; Prodrug; Bioactivation; Screening Method; Chemotherapy; Functional plasticity; Modulated activity; Biokemi;

    Abstract : A screening method was developed for identification of catalytically active enzymes in combinatorial cDNA libraries of mutated glutathione transferase (GST) derivatives expressed in E. coli. The method is based on spraying monochlorobimane (MCB) directly over bacterial colonies growing on agar. READ MORE