Search for dissertations about: "Glycosylation Biomarkers"
Showing result 1 - 5 of 11 swedish dissertations containing the words Glycosylation Biomarkers.
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1. Development and application of alternative methods for profiling proteins N-glycosylation
Abstract : Glycosylation is a post-translational modification (PTM) that exerts profound structural and functional effects on the modified protein. Glycan synthesis and conjugation to proteins are regulated by a myriad of factors, both genetic and environmental, and are also influenced by external stressors. READ MORE
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2. Development and Application of Proximity Assays for Proteome Analysis in Medicine
Abstract : Along with proteins, a myriad of different molecular biomarkers, such as post-translational modifications and autoantibodies, could be used in an attempt to improve disease detection and progression. In this thesis, I build on several iterations of the proximity ligation assay to develop and apply new adaptable methods to facilitate detection of proteins, autoantibodies and post-translational modifications. READ MORE
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3. Development of proteomic methods for studying cerebrospinal fluid proteins involved in Alzheimer´s disease
Abstract : Alzheimer's disease (AD) is the most common cause of dementia in western countries. The main neuropathological findings in the AD brain are senile plaques, neurofibrillary tangles and degeneration of neurons and synapses. READ MORE
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4. Targeting the human glycoproteome: new enrichment protocols and mass spectrometric analyses reveal unique and novel glycosylation sites
Abstract : Glycosylation is one of the most common and structurally diverse posttranslational modifications of proteins. Given that protein glycosylation is involved in various cellular processes, the characterization of site-specific N- and O-linked glycosylations is becoming increasingly important. However, current mass spectrometry-based technologies, i.e. READ MORE
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5. Advances and Applications of Antibody Arrays - Proteomic Profiling of Pancreatic Disease
Abstract : Recombinant antibody microarrays have advanced into indispensable tools for large-scale, high-throughput multiplexed serum proteomics. This thesis, based upon five original papers, deals with the development of an in-house designed antibody microarray platform, and its applications for serum profiling of pancreatic disease. READ MORE