Search for dissertations about: "Glykobiologigruppen"

Found 3 swedish dissertations containing the word Glykobiologigruppen.

  2. 1. Tumor Selective Antiproliferative Naphthoxylosides

    Author : Ulrika Aili; Glykobiologigruppen; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glycosaminoglycan; proteoglycan; heparan sulfate; xyloside; naphthoxyloside; histone H3 acetylation;

    Abstract : Proteoglycans (PG) are highly anionic macromolecules consisting of a core protein covalently substituted with long unbranched polysaccharide chains called glycosaminoglycans (GAGs). PGs are central components in multicellular organisms, and they may occur in the extracellular matrix (ECM), at the cell surface, or in the secretory pathway. READ MORE

  4. 2. Structural and Functional Analyses of Xyloside-primed Glycosaminoglycans

    Author : Andrea Persson; Glykobiologigruppen; []
    Keywords : Glycosaminoglycan; Xyloside; Chondroitin sulfate; Dermatan sulfate; Heparan sulfate; Proteoglycan; Cancer;

    Abstract : Glycosaminoglycans (GAGs) are polysaccharides produced by essentially all mammalian cells. Due to their enormous structural diversity, they are involved in many biological processes both in health and disease, including all stages of tumor progression. READ MORE

  5. 3. Characterization and Crystallization of Anchorless Glypican-1

    Author : Gabriel Svensson Birkedal; Glykobiologigruppen; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; S-nitrosylation; nitric oxide; protein stability; protein conformation; X-ray crystallography; calorimetry; spectroscopy; proteoglycan; glypican; heparan sulfate;

    Abstract : Glypicans are cell-surface heparan sulfate proteoglycans that regulate Wnt, Hedgehog, bone morphogenetic protein, and fibroblast growth factor signaling through their heparan sulfate chains. Recent studies have shown that glypican core proteins also have functional roles in growth factor signaling, but biochemical and structural knowledge regarding the core proteins is limited. READ MORE