Search for dissertations about: "Golgi complex"

Showing result 1 - 5 of 41 swedish dissertations containing the words Golgi complex.

2. 1. Haptoglobin: Biosynthesis and Evolution

   Author : Krzysztof B. Wicher; Erik Fries; John W. M. Creemers; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; haptoglobin; cleavage; C1r-LP; evolution; vertebrate; endoplasmic; Golgi; complement; Molekylärbiologi; Molecular biology; Molekylärbiologi;

   Abstract : Haptoglobin (Hp) is a serum protein known for its ability to form a tight complex with hemoglobin (Hb) and thereby inhibiting the oxidative activity of Hb. Mammalian Hp is synthesized as a precursor (proHp) that undergoes proteolytic cleavage by a previously unidentified enzyme in the endoplasmic reticulum (ER). READ MORE

4. 2. Analysis of Binding Events and Diffusion in Living Cells

   Author : Markus Elsner; Göteborgs universitet; []
   Keywords : COPI; Golgi; Diffusion; Glycosyltransferases; Sorting; Molecular; Crowding;

   Abstract : It is well known that diffusion is the main mode of transport in living cells, but the consequences of diffusion in a complex cellular environment are not generally appreciated. In this thesis, we have investigated several aspects of how diffusion properties influence the observability of cellular binding kinetics and how they can be used to obtain information about the environment of proteins and other molecules. READ MORE

5. 3. Cellular design of heparan sulfate : The NDST enzymes and their regulation

   Author : Pernilla Carlsson; Lena Kjellén; Tarja Kinnunen; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; heparan sulfate; heparin; proteoglycan; NDST; PAPS; Golgi; Cell and molecular biology; Cell- och molekylärbiologi;

   Abstract : Heparan sulfate proteoglycans are proteins with long, unbranched heparan sulfate (HS) polysaccharide chains attached to them. They are found on cell surfaces and in basement membranes where they exert their action by interacting with a wide range of enzymes and signaling molecules and are thereby involved in a range of various processes both during embryonic development and in adult physiology. READ MORE

6. 4. Characterization of p58 and rab1p, two proteins operating at the interface of the endoplasmic reticulum and the Golgi complex

   Author : Ulla Lahtinen; Karolinska Institutet; Karolinska Institutet; []
   Keywords : protein transport; rab1p; p58; animal lectin; intermediate compartment; endoplasmic reticulum; Golgi complex;

   Abstract : Endomembranes participating in the early stages in exocytosis consist of the endoplasmic reticulum (ER), the Golgi complex, and vesicular transport intermediates at their interface. These vesicular transport intermediates were first visualized by following the synchronized transport of a viral membrane protein from the ER to the Golgi complex, which occurs at slower rates at reduced temperatures causing an accumulation of transport vesicles. READ MORE

7. 5. Localisation of Protein Kinase C in Apoptosis and Neurite Outgrowth

   Author : Anna Schultz; Institutionen för translationell medicin; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; onkologi; cancer; Medicine human and vertebrates ; Medicin människa och djur ; Cytology; oncology; cancerology; Cytologi; Prostate Cancer; Neuroblastoma; Ceramide; Golgi Apparatus; Neurite outgrowth; Apoptosis; Protein Kinase C; C1 domain;

   Abstract : Protein kinase C (PKC) is a family of serine/threonine kinases, which are subgrouped into classical (a, bI, bII, g), novel (d, e, h, q) and atypical (z, i/l) isoforms. One major aim of this thesis work was to investigate if altered levels of PKC isoforms influence the apoptotic responses of malignant cell-lines. READ MORE