Search for dissertations about: "Goto-Kakizaki rat"
Showing result 11 - 15 of 25 swedish dissertations containing the words Goto-Kakizaki rat.
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11. Effect of hyperglycemia on glucose transport and intracellular signal transduction in skeletal muscle
Abstract : Recent studies revealing the components of insulin signal transduction have raised the question of whether the defects in insulin signaling account for disturbed glucose metabolism in people with NIDDM. The major focus of this thesis is to elucidate the role of insulin signal transduction in the development of peripheral insulin resistance. READ MORE
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12. Studies on proteins involved in the molecular regulation of insulin exocytosis
Abstract : Type 2 diabetes mellitus is a disease characterized by impaired insulin secretion and insulin resistance. Better understanding of molecular mechanisms of insulin secretion may help to optimize type 2 diabetes management. READ MORE
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13. Role of protein-tyrosine phospatases in insulin and glucagon secretion in pancreatic islets of healthy rats and spontaneously diabetic GK rats
Abstract : Both insulin and glucagon secretion from pancreatic beta- and alpha-cells, respectively, are regulated by nutrients such as glucose and amino acids. In addition, the mechanisms leading to exocytosis of hormones are influenced by kinases and phosphatases that phosphorylate and dephosphorylate regulatory proteins respectively. READ MORE
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14. Roles of voltage-gated Ca2+ channel subunits in pancreatic β cells
Abstract : Hallmarks of type 2 diabetes (T2D) include elevated blood glucose and free fatty acids (FFAs) as a result of impaired β cell insulin secretion and decreased β cell mass. The glucose-stimulated insulin secretion (GSIS) in β cells is triggered by depolarization-evoked Ca2+ entry through voltage-gated Ca2+ (CaV) channels. READ MORE
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15. Anti-diabetic and anti-inflammatory effects of medicinal plants in a type 2 diabetic animal model
Abstract : Medicinal plants have been suggested since ancient times to be a good source of drugs for treating diabetes. The aims of this thesis were to identify the anti-diabetic effects and to understand further the mechanisms involved for two traditional plants, borapetol B (C1) isolated from Tinospora crispa, and Gynostemma pentaphyllum (GP), in diabetic rats. READ MORE