Search for dissertations about: "Goto-Kakizaki rat"
Showing result 16 - 20 of 25 swedish dissertations containing the words Goto-Kakizaki rat.
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16. Assessment of anti-diabetic effect of Vietnamese herbal drugs
Abstract : The prevalence of type 2 diabetes mellitus is increasing in Vietnam as well as in other developing countries (China, Indian subcontinent, and Africa). Searching for hypoglycemic agents with origin from domestic herbals was considered as a useful way to find novel therapy of the disease. After treatment i.p. READ MORE
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17. Studies on factors modulating glucose homeostasis in healthy and diabetic rats
Abstract : Glucose is the most common substrate for energy metabolism. Despite the varying demands for glucose, the body needs to regulate its internal environment and maintain a constant and stable condition. Glucose homeostasis requires harmonized interaction between several tissues, achieving equilibrium between glucose output and uptake. READ MORE
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18. Mechanism of pure glucose-dependent insulinotropic activity of a novel imidazoline compound BL11282
Abstract : We developed a novel, pure glucose-dependent, insulinotropic imidazoline compound, BL11282, which directly affects the insulin exocytotic machinery and does not block the KATP channel activity. BL11282 does not induce insulin secretion at basal glucose concentrations, whereas it stimulates insulin secretion at an elevated glucose level. READ MORE
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19. Effects of imidazoline compounds on intracellular CA2+ and apoptosis
Abstract : Cytoplasmic free Ca2+ concentration ([Ca2+]i) plays a pivotal role in the regulation of insulin release from the pancreatic beta-cell. [Ca2+]i is also important in the control of apoptosis. READ MORE
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20. Bone disease and diabetes mellitus
Abstract : Diabetes Mellitus (DM) and Osteoporosis (OP) frequently co-exist with advanced age and imply large health challenges worldwide. The last decades there has been a growing interest regarding fracture risk in DM. Currently used screening methods (Dual Energy X-ray Absorptiometry (DXA) and FRAX) underestimate fracture risk in diabetes patients. READ MORE