Search for dissertations about: "Goto-Kakizaki rats"

Showing result 1 - 5 of 26 swedish dissertations containing the words Goto-Kakizaki rats.

  2. 1. Protein and mRNA Studies of Rat FA1/Pref-1/dlk

    Author : Gabriella Persdotter Hedlund; Jann Hau; Carina Carlsson; Torgny Stigbrand; Uppsala universitet; []
    Keywords : Laboratory animals; Preadipocyte factor 1; delta like protein; Fetal antigen 1; Goto-Kakizaki; Zucker; adipokines; adipose tissue; diabetes; obesity; Försöksdjursvetenskap;

    Abstract : The timing of cell differentiation is important for development and renewal of well functioning organs and tissues. One protein involved in this process is Preadipocyte factor 1 (Pref-1). Most likely, the role of this protein is to maintain cells in an undifferentiated state. READ MORE

  4. 2. Ischemic brain damage following transient and moderate compression of sensorimotor cortex in Sprague-Dawley and diabetic Goto-Kakizaki rats

    Author : Jurgita Kundrotiené; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Cortical compression; cerebral ischemia; neuroprotection; hyperglycemia; GotoKakizaki rats.;

    Abstract : Several animal models have been developed to facilitate the investigation of biochemical, physiological, and neurological events after cerebral ischemia. In this study we present a new animal model which reliably describes morphological changes and neurological deficits produced by mild to moderate brain ischemia and which can be used to identify novel, potentially useful, neuroprotective agents. READ MORE

  5. 3. Repair and Reconstruction of Peripheral Nerve Injuries. Treatment with G-CSF and Stromal Vascular Fraction

    Author : Hanna Frost; Malmö Handkirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; peripheral nerve injuries; nerve regeneration; reconstructive surgical procedures; diabetes mellitus; rat sciatic nerve; granulocyte colony-stimulating factor; stromal vascular fraction; electrospinning; rats; Schwann cells;

    Abstract : While surgery is a cornerstone in treatment of peripheral nerve injuries, it is not a comprehensive approach, and outcome is unsatisfactory, especially sensory function. The present aim was to translate recent findings about stem- and progenitor cells to improve regenerative outcome, where the cells have to be autologous, available within the same surgical procedure, and minimally manipulated. READ MORE

  6. 4. Recovery from focal brain ischemia induced by extradural compression in diabetic and non-diabetic rats

    Author : Tiago J T Prazeres Moreira; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Focal ischemia; locomotor activity; lever-press task; neurodegeneration; hyperglycemia; Goto-Kakizaki rats; Fluoro-Jade; heme-oxygenase; astrocytes; microglia.;

    Abstract : Cerebrovascular disease and head trauma are among the leading causes of death and disability. In addition to severe motor disturbances, ischemia resulting from stroke or traumatic brain injury (TBI) can cause mild to severe cognitive deficits. READ MORE

  7. 5. Role of protein-tyrosine phospatases in insulin and glucagon secretion in pancreatic islets of healthy rats and spontaneously diabetic GK rats

    Author : Jie Chen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Protein-tyrosine phosphatase; insulin; glucagon; vanadate; type 2 diabetes; pancreatic islets;

    Abstract : Both insulin and glucagon secretion from pancreatic beta- and alpha-cells, respectively, are regulated by nutrients such as glucose and amino acids. In addition, the mechanisms leading to exocytosis of hormones are influenced by kinases and phosphatases that phosphorylate and dephosphorylate regulatory proteins respectively. READ MORE