Search for dissertations about: "Granule serine protease"

Showing result 1 - 5 of 10 swedish dissertations containing the words Granule serine protease.

2. 1. Haematopoietic Serine Proteases : A Cleavage Specificity Analysis

   Author : Michael Thorpe; Lars Hellman; Urban Gullberg; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Mast cell; cleavage specificity; phage display; chymase; serine protease; granzyme; fish protease;

   Abstract : Mast cells are innate immune cells, historically involved in allergy responses involving IgE. Through this, they have earned a reputation as a fairly detrimental cell type. Their beneficial roles remain somewhat enigmatic although they clearly have the ability to modulate the immune system. READ MORE

4. 2. Chymotrypsin/trypsin-related serine proteases : A structural, functional and evolutionary analysis

   Author : Maryam Poorafshar; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; serine proteases; proteoglycans; mast cells; basophils; Biokemi; Biochemistry; Biokemi; immunologi; Immunology;

   Abstract : Is life possible without proteolytic enzymes? Proteases participate in almost everyaspect of life and they can be found throughout the body and in every cell. Mast cells,together with basophils are, two important effector cells of the immune system. READ MORE

5. 3. Sculpted through Time : Evolution and Function of Serine Proteases from the Mast Cell Chymase Locus

   Author : Maike Gallwitz; Lars Hellman; Lars Pilström; Urban Gullberg; Uppsala universitet; []
   Keywords : Immunology; immune system; mast cell; chymase locus; serine protease; evolution; gene duplication; Immunologi;

   Abstract : Immune cells like NK cells, T cells, neutrophils and mast cells store high amounts of granule serine proteases, graspases. Graspases are encoded from the mast cell chymase locus. The human locus holds four genes: α-chymase, cathepsin G, and granzymes H and B. In contrast, the mouse locus contains at least 14 genes. READ MORE

6. 4. The mast cell transcriptome and the evolution of granule proteins and Fc receptors

   Author : Srinivas Akula; Lars Hellman; Sandra Kleinau; Arne Egesten; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Mast cell; Fc receptors; Granule serine protease; Evolution and transcriptome.; Immunologi; Immunology;

   Abstract : Protection against disease-causing pathogens, known as immunity, involves numerous cells organs, tissues and their products. To able to understand the biology of immune cells (hematopoietic cells) and their role in an immune system, we have used several different methods, including transcriptome analyses, bioinformatics, production of recombinant proteins and analyses of some of them, focusing on the granule proteases by substrate phage display. READ MORE

7. 5. Hematopoietic Serine Proteases from the Mast Cell Chymase and Tryptase Loci - a Functional and Evolutionary Analysis

   Author : Jenny Reimer; Lars Hellman; Gunnar Nilsson; Sara Wernersson; Göran Andersson; Uppsala universitet; []
   Keywords : Cell and molecular biology; immune system; mast cell; basophil; mast cell chymase locus; multigene tryptase locus; serine protease; evolution; Cell- och molekylärbiologi;

   Abstract : Mast cells are key effector cells in allergic and inflammatory diseases. However, their primary role is most likely in host defence against parasitic and bacterial infections. Mast cells are a particularly rich source of serine proteases. READ MORE