Search for dissertations about: "Gregg Siegal"

Found 1 swedish dissertation containing the words Gregg Siegal.

2. 1. Fragment Based Drug Discovery with Surface Plasmon Resonance Technology

   Author : Helena Nordström; Helena Danielson; Gregg Siegal; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Fragment based drug discovery; SPR biosensor; matrix metalloproteinase-12; HIV-1 protease; resistance;

   Abstract : Fragment based drug discovery (FBDD) has been applied to two protease drug targets, MMP-12 and HIV-1 protease. The primary screening and characterization of hit fragments were performed with surface plasmon resonance -technology. Further evaluation of the interaction was done by inhibition studies and in one case with X-ray crystallography. READ MORE