Search for dissertations about: "Grignard reagents"

Showing result 1 - 5 of 11 swedish dissertations containing the words Grignard reagents.

  1. 1. Reaction Between Grignard reagents and Heterocyclic N-oxides Synthesis of Substituted Pyridines, Piperidines and Piperazines

    University dissertation from Umeå : Umeå universitet

    Author : Hans Andersson; Umeå universitet.; [2009]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Grignard reagents; pyridine N-oxide; pyrazine N-oxide; dienal-oxime; pyridine; ortho- metalation; piperidine; piperazine; asymmetric; NATURAL SCIENCES Chemistry Organic chemistry Organic synthesis; NATURVETENSKAP Kemi Organisk kemi Organisk syntes; organisk kemi; Organic Chemistry;

    Abstract : This thesis describes the development of new synthetic methodologies for preparation of bioactive interesting compounds, e.g. substituted pyridines, piperidines or piparazines. Thesecompounds are synthesized from commercially available, cheap and easily prepared reagents, videlicet the reaction between Grignard reagents and heterocyclic N-oxides. READ MORE

  2. 2. New C-C coupling Reactions Enabled by Main-group Organometallics

    University dissertation from Stockholm : Department of Organic Chemistry, Stockholm University

    Author : Kilian Colas; Stockholms universitet.; [2018]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; C-C coupling; organometallics; aluminum; magnesium; Grignard; turbo-Hauser-bases; piperazines; sulfur; ketones; Organic Chemistry; organisk kemi;

    Abstract : The carbon-carbon bond has always been at the very core of chemical research. Strategies for the creation of C−C bonds are one of the keys to the construction game that organic chemists play with the building blocks provided by Nature, with the ultimate goal of producing useful molecular structures that will serve society as medicines, materials, imaging tools, catalysts, and ligands (to mention but a few). READ MORE

  3. 3. New Methodologies in Organic Chemistry: Applications to the Synthesis of α-Amino Acids and Natural Products

    University dissertation from Stockholm : Kemi

    Author : Sebastian Hirner; KTH.; [2009]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic synthesis; 2-Vinylaziridines; 3-Pyrrolines; Ringexpansion; Rearrangement; Anisomycin; Total synthesis; α-Amino acids; Arylglycines; Weinreb amides; α-Arylation; Grignard reagents; Umpolung; NATURAL SCIENCES Chemistry Organic chemistry; NATURVETENSKAP Kemi Organisk kemi;

    Abstract : This thesis deals with the development and application of new synthetic methodology in organic chemistry.The first part describes the development of a new protocol for the synthesis of 3-pyrrolines by means of a microwave-assisted ring-expansion reaction of 2-vinylaziridines. READ MORE

  4. 4. Regiocontrol in copper(I)-catalyzed allylic substitution reactions with Grignard reagents : mechanistic and synthetic aspects

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Eva Persson; Uppsala universitet.; [1995]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURAL SCIENCES; NATURVETENSKAP;

    Abstract : .... READ MORE

  5. 5. Iron catalyzed C-C coupling reactions - mechanistic investigations

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Anna Hedström; Göteborgs universitet.; Gothenburg University.; [2013]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; iron; homogenous catalysis; cross coupling; C-C bond formation; reaction mechanisms; kinetic investigations; competitive Hammett study; density functional theory;

    Abstract : The mechanism of the iron catalyzed cross coupling of aryl electrophiles with alkyl Grignard reagents was studied. The reaction proceeds via a rate-limiting oxidative addition of the aryl halide to an Fe(I) complex generated in situ. A transmetalation from an aryl Grignard reagent occurs either before or after the oxidative addition. READ MORE