Search for dissertations about: "Gst"

Showing result 1 - 5 of 63 swedish dissertations containing the word Gst.

  2. 1. Insurance in European VAT : On the Current and Preferred Treatment in the Light of the New Zealand and Australian GST Systems

    Author : Marta Papis-Almansa; Institutionen för handelsrätt; []
    Keywords : SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; insurance; EU law; tax law; European VAT; value added tax; goods and services tax; Australian GST; New Zealand GST; exemptions from VAT; financial services; comparative tax law;

    Abstract : Whether and how to tax insurance, one of the crucial elements of the modern economy and society, is a complex issue for the design of laws on value added tax (VAT). Exemption from VAT has been the most common international practice, and it is also applied in the harmonized system of European VAT. READ MORE

  4. 2. Mutational Analysis and Redesign of Alpha-class Glutathione Transferases for Enhanced Azathioprine Activity

    Author : Olof Modén; Bengt Mannervik; Mikael Widersten; Kenneth Tew; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; allelic variants; azathioprine; bioactivation; chimeric mutagenesis; directed evolution; DNA shuffling; enzyme engineering; glutathione transferase; GST; lysate screening; molecular docking; multiple alignment; multivariate analysis; polymorphism; principal component analysis; prodrug; prodrug activation; protein engineering; protein redesign; reduced amino acid alphabet; saturation mutagenesis; semi-rational enzyme engineering; site-directed mutagenesis; structure-activity relationship; structure-based redesign; Biokemi; Biochemistry;

    Abstract : Glutathione transferase (GST) A2-2 is the human enzyme most efficient in catalyzing azathioprine activation. Structure-function relationships were sought explaining the higher catalytic efficiency compared to other alpha class GSTs. READ MORE

  5. 3. Genetic modification of cholera toxin B subunit for mucosal anti-infectious or anti-pathologic vaccination

    Author : Hamid Sadeghi; Göteborgs universitet; []
    Keywords : Genetic fusion protein; cholera toxin B subunit; insulin; GST; Oral tolerance;

    Abstract : The development of mucosal vaccines requires antigen delivery systems that can efficiently help to present vaccine antigens to the mucosal immune system. En efficient and well known antigen carrier/delivery system is the B subunit of cholera toxin (CTB). READ MORE

  6. 4. Exploring the steroidogenic activity of glutathione transferases across species

    Author : Helena Lindström; Bengt Mannervik; Kjell Wikvall; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Glutathione transferase; steroidogenesis; GST A3-3; testis; androstenedione; pregnenedione; equine; steroidogenesis inhibition; Drosophila GSTE14; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : Glutathione transferases (GSTs) comprise a superfamily of enzymes prominently involved in detoxication. However, some GSTs have developed alternative functions. READ MORE

  7. 5. A Novel Route for Construction of Multipurpose Receptors through Chemical Modification of Glutathione Transferases

    Author : Johan Viljanen; Bengt Harald Jonsson; Kerstin Broo; Sophia Hober; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Human GST A1-1; site-specific covalent modification; tyrosine 9; lysine 216; methionine 208; multipurpose receptor; pattern recognition; protein purification; Chemistry; Kemi;

    Abstract : This thesis describes how the human Alpha class glutathione transferase (GST) A1-1 can be reprogrammed either to function as a multipurpose biosensor for detection of small molecule analytes, or as a handle providing for more efficient protein purification.A novel, user-friendly, and efficient method for site-specific introduction of functional groups into the active site of hGST A1-1 is the platform for these achievements. READ MORE