Search for dissertations about: "Gunilla Enblad"

Showing result 16 - 20 of 26 swedish dissertations containing the words Gunilla Enblad.

  2. 16. Posttransplant Lymphoproliferative Disorders : Studies of Epstein-Barr Virus, Regulatory T Cells and Tumor Origin

    Author : Amelie Kinch; Karlis Pauksens; Gunilla Enblad; Eva Baecklund; Harald Holte; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PTLD; Lymphoma; Epstein-Barr Virus; EBV DNAemia; FoxP3; Treg; Microenvironment; Cell of Origin; Recipient; Transplantation; Immunosuppression; Hepatitis C; Survival; Medicinsk vetenskap; Medical Science;

    Abstract : Epstein-Barr virus (EBV) infects almost all humans and establishes lifelong latency in B cells. Posttransplant lymphoproliferative disorder (PTLD) is a rare but serious complication after transplantation triggered by immunosuppression and often related to EBV infection. READ MORE

  4. 17. Stereotyped B Cell Receptors in Chronic Lymphocytic Leukaemia : Implications for Antigen Selection in Leukemogenesis

    Author : Fiona Murray; Richard Rosenquist Brandell; Kostas Stamatopoulos; Gunilla Enblad; Gerard Tobin; Manlio Ferrarini; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chronic lymphocytic leukaemia; immunoglobulin genes; somatic hypermutation; stereotyped B cell receptors; antigen selection; Molecular biology; Molekylärbiologi;

    Abstract : Biased immunoglobulin heavy variable (IGHV) gene usage and distinctive B-cell receptor (BCR) features have been reported in chronic lymphocytic leukaemia (CLL), which may reflect clonal selection by antigens during disease development. Furthermore, the IGHV gene mutation status distinguishes two clinical entities of CLL, where patients with unmutated IGHV genes have an inferior prognosis compared to those with mutated IGHV genes. READ MORE

  5. 18. Clinical and tumour biology studies of Diffuse Large B-cell Lymphoma : with emphasis on comorbidity, toxicity and outcome

    Author : Charlott Mörth; Gunilla Enblad; Kristina Drott; Uppsala universitet; []
    Keywords : DLBCL; autoimmune disease; cardiac toxicity; neurotoxicity; EFS; OS; Medicinsk vetenskap; Medical Science;

    Abstract : Diffuse large B-cell lymphoma (DLBCL) is curable in around 70% when treated with standard immunochemotherapy R- CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone). Treatment related toxicity affecting survivors is a clinical problem as well as comorbidities influencing the possibility to give adequate treatment. READ MORE

  6. 19. Intratumoral Predictive Markers in Metastatic Renal Cancer Patients

    Author : Marjut Niinivirta; Gustav Ullenhag; Gunilla Enblad; Sten Nilsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Renal cell cancer; predictive marker; tyrosine kinase inhibitor; tissue microarray; cubilin; annexin A1; PKLR; ELTD1; Oncology; Onkologi;

    Abstract : There is no established predictive marker for the treatment of metastatic renal cell cancer (mRCC) patients. With a predictive marker, patients unlikely to respond could be selected upfront and offered other therapy options. Thereby, unnecessary toxicity could be avoided and costs would be reduced. READ MORE

  7. 20. Dilemmas in palliative chemotherapy when approaching end-of-life

    Author : Ulla Näppä; Bertil Axelsson; Birgit H Rasmussen; Olav Lindqvist; Gunilla Enblad; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; chemotherapy; decision-making; dilemma; palliative care; performance status; questionnaire; registered nurse; kyselylomake; ongelma; palliatiivinen hoito; päätöksenteko; sairaanhoitaja; sytostaattihoito; syöpä; yleistila; allmäntillstånd; beslutsprocess; cancer; cytostatika; dilemma; enkät; palliativ vård; sjuksköterska; onkologi; Oncology;

    Abstract : Background When cure is no longer possible, medical care should aim for a transition to palliative care regardless of disease. Patients with incurable cancer are often treated with palliative chemotherapy (PCT), starting with the intent to prolong life and increase quality of life. READ MORE