Search for dissertations about: "Gunnar Pejler"
Found 5 swedish dissertations containing the words Gunnar Pejler.
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1. The Impact of Tryptase and Epigenetic Mechanisms on Mast Cells
Abstract : Mast cells have a large influence on multiple immune-mediated responses, including allergic conditions, and they have been implicated in various diseases such as arthritis and cancer. Mastocytosis is characterized by abnormal mast cell proliferation induced by mutations in KIT, the stem cell factor (SCF) receptor. READ MORE
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2. Mechanisms in Tendon Healing : Pain, Biomarkers and the Role of Mast Cells
Abstract : Tendon injuries and tendinopathy are common disorders, but the underlying mechanisms are not well understood. The overall aim of this thesis was to better understand the mechanisms underlying tendon healing, pain, and inflammation. READ MORE
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3. Cleavage Specificity of Mast Cell Chymases
Abstract : Mast cells (MC) are potent inflammatory cells that are known primarily for their prominent role in IgE mediated allergies. However, they also provide beneficial functions to the host, e.g. in bacterial and parasitic defence. READ MORE
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4. Induction of Mast Cell Apoptosis via Granule Permeabilization : A Novel Approach to Target Mast Cells
Abstract : Mast cells are densely granulated tissue-resident immune cells that play an important role in orchestrating inflammatory responses. Dysregulated increases in the numbers and activation status of mast cells can have deleterious consequences for the body in various inflammatory diseases. READ MORE
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5. N-Sulfation and Polymerization in Heparan Sulfate Biosynthesis
Abstract : Heparan sulfate (HS) is a glycosaminoglycan present in all cell types covalently attached to core proteins forming proteoglycans. HS interacts with different proteins and thereby affects a variety of processes. READ MORE