Search for dissertations about: "Gunnar Pejler"

Found 4 swedish dissertations containing the words Gunnar Pejler.

  1. 1. Mechanisms in Tendon Healing : Pain, Biomarkers and the Role of Mast Cells

    Author : Abdul Alim; Magnus Peterson; Gunnar Pejler; Per Kristiansson; Paul W. Ackermann; Gustav Andersson; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; Tendon Healing; Pain; Biomarkers; Mast Cells; Inflammation; Microdialysis; Neurotransmitters; Glutamate Receptors; Procollagen; Transcriptional factors; Biologi med inriktning mot molekylär immunologi; Biology with specialization in Molecular Immunology; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi; Neuroscience; Neurovetenskap;

    Abstract : Tendon injuries and tendinopathy are common disorders, but the underlying mechanisms are not well understood. The overall aim of this thesis was to better understand the mechanisms underlying tendon healing, pain, and inflammation. READ MORE

  2. 2. Cleavage Specificity of Mast Cell Chymases

    Author : Mattias K. Andersson; Lars Hellman; Gunnar Pejler; Per Venge; Uppsala universitet; []
    Keywords : Biology; Immunology; Mast cell; Serine protease; Chymase; Cleavage specificity; Phage display; Biologi;

    Abstract : Mast cells (MC) are potent inflammatory cells that are known primarily for their prominent role in IgE mediated allergies. However, they also provide beneficial functions to the host, e.g. in bacterial and parasitic defence. READ MORE

  3. 3. Induction of Mast Cell Apoptosis via Granule Permeabilization : A Novel Approach to Target Mast Cells

    Author : Aida Paivandy; Gunnar Pejler; Magda Babina; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Mast cells; Granules; Apoptosis; Reactive oxygen species; ROS; Lysosomotropic agents; Mefloquine; Immunologi; Immunology; Biokemi; Biochemistry;

    Abstract : Mast cells are densely granulated tissue-resident immune cells that play an important role in orchestrating inflammatory responses. Dysregulated increases in the numbers and activation status of mast cells can have deleterious consequences for the body in various inflammatory diseases. READ MORE

  4. 4. N-Sulfation and Polymerization in Heparan Sulfate Biosynthesis

    Author : Jenny Presto; Lena Kjellén; Gunnar Pejler; Anders Malmström; Uppsala universitet; []
    Keywords : Cell and molecular biology; Heparan sulfate; N-deacetylase N-sulfotransferase; NDST; EXT1; EXT2; Biosynthesis; Cell- och molekylärbiologi;

    Abstract : Heparan sulfate (HS) is a glycosaminoglycan present in all cell types covalently attached to core proteins forming proteoglycans. HS interacts with different proteins and thereby affects a variety of processes. READ MORE