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Showing result 1 - 5 of 69 swedish dissertations matching the above criteria.

2. 1. Stem cell transplantation : home care, graft-versus-host disease and costs

   Author : Britt-Marie Svahn; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Stem-cell transplantation; home-care; GVHD; costs;

   Abstract : Allogeneic stem-cell transplantation (ASCT) is used to treat malignant and non-malignant diseases of the immunohematopoietic system. Results in terms of survival rate and less complications are continually improving due to better knowledge, supportive care, immunosuppression, new drugs against infections and HLA-typing techniques. READ MORE

4. 2. Multipotent mesenchymal stromal cell transplantation : possible viral complications and alloimmunity

   Author : Mikael Sundin; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Mesenchymal stem cell; immunogenicity; viruses; transplantation; antibodies; GvHD;

   Abstract : In the last few years, human multipotent mesenchymal stromal cells (MSC) have been increasingly used in novel therapeutic strategies due to their intrinsic immunosuppressive, anti-inflammatory and regenerative properties. In hematopoietic stem cell transplantation (HSCT), a curable treatment of hematological malignancies and several non-malignant conditions, MSC have been used as a therapy for graft-versus host-disease (GvHD) and other complications. READ MORE

5. 3. Leukaemic relapse after allogeneic haematopoietic stem cell transplantation and the use of the graft-versus-leukaemia effect

   Author : Stefan Carlens; Karolinska Institutet; Karolinska Institutet; []
   Keywords : haematopoietic stem cell transplantation; GVHD; GVL; DLI; T-cell culture; retroviral transduction; NK-cell culture;

   Abstract : Survival after allogeneic haematopoietic stem cell transplantation (HSCT) has improved over the last decades due to improvements in immunosuppressive regimens and supportive care. Today the major risk of treatment failure is recurrent leukaemia, a risk which has stayed relatively constant over the years. READ MORE

6. 4. Vector development for suicide gene therapy

   Author : Alar Aints; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Suicide gene therapy; VP22; selection markers; Ouabain resistance gene; GvHD; retroviral gene transfer;

   Abstract : Gene therapy is used to treat conditions that arise from errors in the genetic makeup of cells either congenital diseases resulting from a deletion or mutation in a gene or malignant diseases where genetic regulation mechanisms have been deranged. Suicide gene therapy is one of several gene therapeutic approaches to treat cancer. READ MORE

7. 5. Graft-versus-Host Disease: Eosinophils, Chimerism and Clinical Features in Patients Undergoing Allogeneic Hematopoietic Stem Cell or Multivisceral Transplantation

   Author : Julia Cromvik; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; graft-versus-host disease; eosinophilic granulocyte; intestinal transplantation; multivisceral transplantation; chimerism analysis;

   Abstract : Abstract Graft-versus-host disease (GVHD) is a potentially severe complication that may develop after allogeneic hematopoietic stem cell transplantation (HSCT). It can also occur after transplantation with isolated intestinal grafts or after multivisceral transplantation (MVTX). GVHD is difficult to diagnose. READ MORE