Search for dissertations about: "Gyrase"

Showing result 1 - 5 of 8 swedish dissertations containing the word Gyrase.

  2. 1. Resistance to Fluoroquinolones in Escherichia coli: Prevention, Genetics and Fitness Costs

    Author : Linda L. Marcusson; Diarmaid Hughes; Karl Drlica; Uppsala universitet; []
    Keywords : Biology; Fluoroquinolone; Escherichia coli; Resistance; Gyrase; Topoisomerase IV; MPC; Fitness compensation; Urinary Tract Infection; Biologi;

    Abstract : Antibiotic-resistant bacteria are increasingly a major healthcare problem but very few new classes of antibiotics have been discovered or launched in recent decades. Approaches to dealing with the problem include learning how bacteria evolve to resistance and improving dosing regimens with current antibiotics so as to reduce the selection of resistant bacteria. READ MORE

  4. 2. Biased Evolution : Causes and Consequences

    Author : Gerrit Brandis; Diarmaid Hughes; Erik Böttger; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Evolution; Codon usage bias; Post-transcriptional regulation; Recombination; Inversion; EF-Tu; Frameshift suppression; Antibiotic resistance; Rifampicin; Ciprofloxacin; Compensatory evolution; Drug efflux; RNA polymerase; DNA gyrase; Mikrobiologi; Microbiology;

    Abstract : In evolution alternative genetic trajectories can potentially lead to similar phenotypic outcomes. However, certain trajectories are preferred over others. These preferences bias the genomes of living organisms and the underlying processes can be observed in ongoing evolution. READ MORE

  5. 3. Mechanisms of resistance to ciprofloxacin in Neisseria gonorrhoeae

    Author : Emma Lindbäck; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Neisseria gonorrhoeae; ciprofloxacin; DNA-gyrase; topoisomerase IV; major outer membrane protein;

    Abstract : A few years ago, most strains of Neisseria gonorrhoeae were susceptible to ciprofloxacin, but after introduction as a first line therapy, resistant strains emerged. Ciprofloxacin inhibit two enzymes necessary for DNA replication. READ MORE

  6. 4. Chromosomal antibiotic resistance mechanisms in Pseudomonas aeruginosa and Neisseria gonorrhoeae

    Author : Sohidul Islam; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The progressive increase in fluoroquinolone resistant N. gonorrhoeae and emergence of multiple antibiotic resistant P. aeruginosa are growing concerns among physicians and health policy makers. In N. READ MORE

  7. 5. Constraints on up-regulation of drug efflux in the evolution of ciprofloxacin resistance

    Author : Lisa Praski Alzrigat; Diarmaid Hughes; Fernando Baquero; Uppsala universitet; []
    Keywords : ciprofloxacin; antibiotic resistance; drug efflux; bacterial fitness; marR; acrR; marA; experimental evolution; Mikrobiologi; Microbiology;

    Abstract : The crucial role of antibiotics in modern medicine, in curing infections and enabling advanced medical procedures, is being threatened by the increasing frequency of resistant bacteria. Better understanding of the forces selecting resistance mutations could help develop strategies to optimize the use of antibiotics and slow the spread of resistance. READ MORE