Search for dissertations about: "Håkan Hedman"

Showing result 1 - 5 of 14 swedish dissertations containing the words Håkan Hedman.

  1. 1. Regulation of leukocyte integrin adhesiveness

    Author : Håkan Hedman; Erik Lundgren; Umeå universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lymphocytes; Cell Adhesion; Integrins; LFA-1; VLA-4; ICAM-1; VCAM-1; Microvesicles; Protein Kinases; Protein Phosphatases;

    Abstract : .... READ MORE

  2. 2. Investigations of Leucine-rich repeats and immunoglobulin-like domain-proteins 1 and 2 (LRIG1 and LRIG2) and their genes in cancer

    Author : Mahmood Faraz; Håkan Hedman; Roger Henriksson; Rolf Bjerkvig; Umeå universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LRIG1; LRIG2; PDGFR; glioma; interactome; breast cancer; prognosis; onkologi; Oncology;

    Abstract : The mammalian leucine-rich repeats and immunoglobulin-like domains (LRIG) gene family consists of three different members, LRIG1, LRIG2, and LRIG3. These genes are expressed in all human and mouse tissues analyzed to date. READ MORE

  3. 3. Quantitative analysis of melanoma transcripts : with emphasis on methodological and biological variation

    Author : Malin Farnebäck; Håkan Hedman; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : The introduction of RT-PCR made it possible to detect circulating tumor cells in melanoma patients by analysis of melanoma-associated transcripts, especially tyrosinase. Since the development of the first PCR method for tyrosinase mRNA, several studies have presented varying results. READ MORE

  4. 4. Cellular Studies of HER-family Specific Affibody Molecules

    Author : Lovisa Göstring; Lars Gedda; Jörgen Carlsson; Fredrik Frejd; Håkan Hedman; Uppsala universitet; []
    Keywords : EGFR; HER2; HER3; Affibody; internalisation; tumour targeting; MEDICINE; MEDICIN;

    Abstract : The human epidermal growth-factor like receptor (HER) family of receptor tyrosine kinases are important targets for cancer therapy. The family consists of four members - EGFR, HER2, HER3 and HER4 - that normally transfer stimulatory signals from extracellular growth factors to the intracellular signalling network. READ MORE

  5. 5. Identification and investigations of leucine-rich repeats and immunoglobulin-like domains protein 2 (LRIG2)

    Author : Camilla Holmlund; Håkan Hedman; Roger Henriksson; Monica Nistér; Umeå universitet; []
    Keywords : LRIG; PDGF; oligodendroglioma; MEDICINE; MEDICIN; onkologi; Oncology;

    Abstract : Receptor tyrosine kinases (RTKs) constitute a family of proteins controlling cell growth and proliferation and whose activities are tightly controlled in normal cells. LRIG1 is a negative regulator of RTK signaling and is a proposed tumor suppressor. The aim of this thesis was to identify and study possible paralogs of LRIG1. READ MORE