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Showing result 1 - 5 of 16 swedish dissertations matching the above criteria.

2. 1. Studies of the vitamin A transporting protein complex retinol-binding protein-transthyretin

   Author : Håkan Melhus; Uppsala universitet; []
   Keywords : MEDICINE; MEDICIN;

   Abstract : .... READ MORE

4. 2. Improving the Quality and Safety of Drug Use in Hospitalized Elderly : Assessing the Effects of Clinical Pharmacist Interventions and Identifying Patients at Risk of Drug-related Morbidity and Mortality

   Author : Anna Alassaad; Håkan Melhus; Margareta Hammarlund-Udenaes; Johan Sundström; Claes Mörlin; Lene Juel Kjeldsen; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adverse drug events; inappropriate prescribing; medication errors; polypharmacy; medication reconciliation; medication review; patient drug counseling; multi-dose dispensed drugs; risk-estimation; multiprofessional collaboration; prediction model; quality measure; rehospitalization;

   Abstract : Older people admitted to hospital are at high risk of rehospitalization and medication errors. We have demonstrated, in a randomized controlled trial, that a clinical pharmacist intervention reduces the incidence of revisits to hospital for patients aged 80 years or older admitted to an acute internal medicine ward. READ MORE

5. 3. Benefits and harms of Bisphosphonates : an observational study

   Author : Jonathan Bergman; Peter Nordström; Miia Kivipelto; Håkan Melhus; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; osteoporosis; fracture; alendronate; risedronate; zoledronic acid; glucocorticoid; mortality; osteonecrosis; register; registry; real-world evidence; epidemiology; Geriatrics; geriatrik; epidemiologi; Epidemiology;

   Abstract : Background: Bisphosphonates are first-line treatment for osteoporosis, but osteoporosis is considered an undertreated disease. The general aim of this dissertation was to further study the benefits and harms of bisphosphonates. READ MORE

6. 4. Analysis of Complex Genetic Traits in Population Cohorts using High-throughput Genotyping Technology

   Author : Andreas Dahlgren; Ann-Christine Syvänen; Håkan Melhus; Markus Perola; Struan Grant; Uppsala universitet; []
   Keywords : Molecular medicine; SNP; TCF7L2; HHEX; COL11A1; ESR1; body height; type 2 diabetes mellitus; proinsulin; ULSAM; complex genetic trait; genotyping technology; Molekylärmedicin;

   Abstract : Most human traits and common diseases have a complex genetic makeup involving more than one gene. The work presented in this thesis investigates standing body height and the common disease type 2 diabetes mellitus (T2DM). READ MORE

7. 5. Interindividual Variability of Drug Transport Proteins : Focus on Intestinal Pgp (ABCB1) and BCRP (ABCG2)

   Author : Gunilla Englund; Per Artursson; Håkan Melhus; Andreas Kindmark; Joseph W Polli; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; membrane transport proteins; ATP-Binding Cassette Transporters; P-glycoprotein; Breast Cancer Resistance Protein; Interindividual variability; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

   Abstract : The appearance of adverse drug reactions is a common reason for hospitalization in Western countries. Research on underlying biological mechanisms for interindividual variability in drug response aims to better identify patients with exceptional genetic traits, disease conditions or risk of drug-drug interactions and thereby help to prevent adverse drug reactions. READ MORE