Search for dissertations about: "H-phosphonate"

Showing result 1 - 5 of 11 swedish dissertations containing the word H-phosphonate.

2. 1. Studies on Oxidative Couplings in H-Phosphonate Chemistry

   Author : Johan Nilsson; Jacek Stawinski; Esther Kuyl-Yeheskiely; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; oxidative coupling; H-phosphonate; H-phosphonothioate; organisk kemi; Organic chemistry; Organisk kemi;

   Abstract : In this thesis oxidative coupling of H-phosphonate and H phosphonothioate diesters with different alcohols and amines are presented. Since the reactions with alcohols previously have been particularly unfavourable due to competing side reactions, a modified protocol leading to high coupling yields of structurally diverse hydroxylic components was developed. READ MORE

4. 2. Expanding the H-phosphonate and H-phosphonothioate chemistry towards biologically important phosphate analogs

   Author : Gaston Lavén; Jacek Stawinski; Wojciech T. Markiewicz; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Phosphonate; phosphonothioate; H-phosphonate; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

   Abstract : This thesis focuses on chemical transformations of H-phosphonate and H-phosphonothioate and can be divided in two parts. The first part, is devoted to the development of the palladium-catalyzed P-C bond formation. Both mechanistic and synthetic studies of the transformations have been performed. READ MORE

5. 3. Towards synthesis of biologically important phosphate analogues : exploring H-phosphonate and C-phosphonate chemistry

   Author : Annika Kers; Robert Letsinger; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic Chemistry; organisk kemi;

   Abstract : This thesis is based on studies directed towards the development of methods for the preparation of phosphorus containing natural products, with the focus on C-phosphonate nucleic acid analogues.Mechanistic studies concerning formation of the phosphorus-carbon bond resulted in development of two efficient protocols for the synthesis of C-phosphonates from the corresponding H-phosphonate derivatives. READ MORE

6. 4. Nucleoside phosphoramidates and related compounds : development of synthetic methods based on H-phosphonate chemistry

   Author : Inger Kers; Wojciech J. Stec; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic Chemistry; organisk kemi;

   Abstract : In this thesis, studies directed towards development of new synthetic methods for the preparation of nucleotide analogues of potential medical value as antisense, antigene or antiviral agents, are described.Two methods for synthesis of N3'->P5' and P3'->N5' phosphoramidate analogues with the nitrogen atom in bridging position of the internucleotide linkage was developed. READ MORE

7. 5. Studies on nucleoside H-phosphonoselenoate chemistry and chalcogen exchange reaction between P(V) and P(III) compounds

   Author : Martin Kullberg; Jacek Stawinski; Wojciech Markiewicz; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Phosphorus chemistry; H-phosphonate; H-phosphonoselenoate; nucleotide analogues; selenization; selenium transfer; phosphoroselenoate; Organic chemistry; Organisk kemi;

   Abstract : In this thesis, the chemistry of compounds containing P-Se bonds has been studied. As a new addition to this class of compounds, H-phosphonoselenoate monoesters, have been introduced and two synthetic pathways for their preparation have been developed. READ MORE