Search for dissertations about: "H-phosphonothioate"
Found 4 swedish dissertations containing the word H-phosphonothioate.
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1. Studies on Oxidative Couplings in H-Phosphonate Chemistry
Abstract : In this thesis oxidative coupling of H-phosphonate and H phosphonothioate diesters with different alcohols and amines are presented. Since the reactions with alcohols previously have been particularly unfavourable due to competing side reactions, a modified protocol leading to high coupling yields of structurally diverse hydroxylic components was developed. READ MORE
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2. Expanding the H-phosphonate and H-phosphonothioate chemistry towards biologically important phosphate analogs
Abstract : This thesis focuses on chemical transformations of H-phosphonate and H-phosphonothioate and can be divided in two parts. The first part, is devoted to the development of the palladium-catalyzed P-C bond formation. Both mechanistic and synthetic studies of the transformations have been performed. READ MORE
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3. Nucleoside H-phosphonates and H-phosphonothioates : some chemical and stereochemical studies
Abstract : Phosphonic acid's reaction towards sterically hindered acyl chlorides has been investigated. A new synthetic method for the synthesis of nucleoside Hphosphonate monoesters has been developed. Furthermore, a method for the synthesis of nucleoside H-phosphonothioate monoesters has also been developed. READ MORE
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4. Studies on the synthesis of nucleotide analogues containing P-F and P-Se bonds
Abstract : In the present work, new synthetic approaches to the synthesis of nucleoside phosphorofluoridate and phosphorofluoridothioate diesters have been developed. These procedures involve either oxidative transformation of the corresponding H-phosphonate or H-phosphonothioate diesters in the presence of fluoride anion or iodine-promoted desulfurization of phosphorothioate or phosphorodithioate diesters in the presence of fluoride anion. READ MORE
