Search for dissertations about: "H. -Y Li"

Showing result 1 - 5 of 49 swedish dissertations containing the words H. -Y Li.

  1. 1. Conformationally Constrained Oligonucleotides for RNA Targeting

    Author : Qing Li; Jyoti Chattopadhyaya; Li-He Zhang; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; conformationally constrained nucleoside; antisense oligonucleotide; RNA affinity; nuclease stability; RNase H; RNA degradation; Chemistry with specialization in Bioorganic Chemistry; Kemi med inriktning mot bioorganisk kemi;

    Abstract : A short oligonucleotide sequence as in a single-stranded antisense oligo nucleotides (AON) or in double-stranded small interfering RNAs (siRNA) can modulate the gene expression by targeting against the cellular mRNA, which can be potentially exploited for therapeutic purposes in the treatment of different diseases. In order to improve the efficacy of oligonucleotide-based drugs, the problem of target affinity, nuclease stability and delivery needs to be addressed. READ MORE

  2. 2. Synthesis and Characterization of ZnO Nanostructures

    Author : Li Li Yang; Qingxiang Zhao; Magnus Willander; Jinghai Yang; Noel Magnea; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Zinc oxide; nanostructures; heterostructures; controllable growth; optical properties; postannealing; diffusion coefficient; Semiconductor physics; Halvledarfysik;

    Abstract : One-dimensional ZnO nanostructures have great potential applications in the fields of optoelectronic and sensor devices.  Therefore, it is very important to realize the controllable growth of one-dimensional ZnO nanostructures and investigate their properties. READ MORE

  3. 3. Approximate Methods of Optimal Control via Dynamic Programming Models

    Author : Yuchao Li; Jonas Mårtensson; Karl H. Johansson; Moritz Diehl; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Optimal Control; Dynamic Programming; Rollout; Model Predictive Control; Electrical Engineering; Elektro- och systemteknik;

    Abstract : Optimal control theory has a long history and broad applications. Motivated by the goal of obtaining insights through unification and taking advantage of the abundant capability to generate data and perform online simulation, this thesis studies the discrete-time infinite horizon optimal control problems and introduces some approximate solution methods via abstract dynamic programming (DP) models. READ MORE

  4. 4. Approximate Solution Methods to Optimal Control Problems via Dynamic Programming Models

    Author : Yuchao Li; Jonas Mårtensson; Karl H. Johansson; Pontus Giselsson; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Optimal control; dynamic programming; model predictive control; Electrical Engineering; Elektro- och systemteknik; Optimization and Systems Theory; Optimeringslära och systemteori;

    Abstract : Optimal control theory has a long history and broad applications. Motivated by the goal of obtaining insights through unification and taking advantage of the abundant capability to generate data, this thesis introduces some suboptimal schemes via abstract dynamic programming models. READ MORE

  5. 5. Effect of Hyaluronan-activation of CD44 on Cell Signaling and Tumorigenesis

    Author : Lingli Li; Paraskevi Heldin; Raija H. Tammi; Uppsala universitet; []
    Keywords : Biomedicine; Hyaluronan; CD44; growth factors; chemokines; tumorigenesis; wound healing; cell signaling; Biomedicin;

    Abstract : Hyaluronan (HA), a structural component in the extracellular matrix (ECM), has been recognized as a signaling molecule. It is important during various biological activities such as embryogenesis, angiogenesis, wound healing and tumor progression. READ MORE