Search for dissertations about: "HBV DNA"

Showing result 1 - 5 of 15 swedish dissertations containing the words HBV DNA.

  1. 1. Hepatitis B virus RNA in serum and liver tissue - quantification using digital PCR

    Author : Kasthuri Prakash; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hepatitis B virus; NTCP; HBV DNA; HBV RNA; subviral particles; integrations; droplet digital PCR;

    Abstract : Hepatitis B virus (HBV) infection is a global health issue that is responsible for approximately 900,000 deaths each year, by inducing liver cirrhosis and hepatocellular carcinoma (HCC). A few markers are used to classify HBV infection and monitor treatment efficacy, including HBV DNA, surface antigen (HBsAg) and e antigen (HBeAg) in serum as well as HBV DNA and RNA in liver tissue. READ MORE

  2. 2. Hepatitis B virus infection and genomic changes from a long-term perspective

    Author : Jonas Bläckberg; Sektion III; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Infektioner; Infections; cor promoter; precore; occult infection; HBV; mutation;

    Abstract : Hepatitis B virus is a non-cytopathic virus with a small, circular, partially double-stranded DNA of 3.2 kb. It causes acute and chronic inflammatory liver disease and hepatocellular carcinoma (HCC). Retesting of stored sera from an outbreak of acute hepatitis in 1969-72 allowed identification of 126 cases of acute hepatitis B. READ MORE

  3. 3. Hepatitis B virus replication and integration

    Author : Simon B. Larsson; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; hepatitis B virus; replication; integration; HBV DNA; HBsAg;

    Abstract : Chronic infection with hepatitis B virus (HBV) affects 240 million people worldwide and may cause liver disease including hepatocellular carcinoma (HCC). Initially patients have high levels of HBV DNA in their blood, no liver disease and express the e antigen (HBeAg). READ MORE

  4. 4. Structure and Dynamics of the Hepatitis B Virus Encapsidation Signal Revealed by NMR Spectroscopy

    Author : Sara Flodell; Stephan Grzesiek; Umeå universitet; []
    Keywords : HBV; RNA; isotope labelling; NMR; structure determination; medicinsk biokemi; Medical Biochemistry;

    Abstract : This thesis describes the study of the three-dimensional structure and dynamics of the hepatitis B virus (HBV) encapsidation signal, epsilon, by means of nuclear magnetic resonance (NMR) and mutational data. HBV replicates by reverse transcription of an RNA pregenome into the viral DNA genome, which becomes enclosed in viral particles (encapsidation). READ MORE

  5. 5. Immune modulation in chronic HBV and HCV infection

    Author : Catharina Hultgren; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; HBV; HBeAg; HCV; NS3; chronic infection; humoral cellular immune response; Th1 Th2 cells; proliferative response;

    Abstract : Chronic viral hepatitis is a major health problem worldwide. The two major viral causes for chronic hepatitis are the hepatitis B (HBV) and C viruses (HCV). HBV is a DNA virus with a rather limited genetic variability whereas HCV is an RNA virus with a high genetic variability. READ MORE