Search for dissertations about: "HDAC"
Showing result 1 - 5 of 37 swedish dissertations containing the word HDAC.
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1. HOST EPIGENETIC REGULATOR BMI1 AND VIRAL FIBER PROTEIN FOR EQUILIBRIUM BETWEEN ADENOVIRUS AND HOST
Abstract : Human adenoviruses (Ads) are broadly used in cancer gene therapy, vaccine development and gene delivery. The modified Ad5 or Ad2 viruses have been successfully used as oncolytic agents in pre-clinical studies. However they could not be translated into clinic utility due to a number of limitations including inefficient Ad spread among tumor cells. READ MORE
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2. Characterisation of CtBP : A Co-Repressor of Transcription that Interacts with the Adenovirus E1A Protein
Abstract : In this study, adenovirus E1A has been used to target and analyse the transcriptional function of the cellular C-terminal Binding Protein (CtBP).Transcription is a complex biochemical process that represents a major regulatory step in gene expression. READ MORE
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3. Protein Acetylation – A Multifunctional Regulator of TGF-β Signaling
Abstract : Transforming growth factor β (TGF-β) is a member of a large family of cytokines that regulate many crucial events in cells, including proliferation, differentiation, migration and apoptosis. Deregulated TGF-β signaling is associated with various forms of cancers and developmental disorders. READ MORE
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4. Adenovirus-mediated Gene Therapy of Prostate Cancer
Abstract : Adenovirus-mediated gene therapy is a potential complement to standard cancer treatments. Advantages are that vectors can be used to target tumors and that replicating viruses lead to increased therapeutic dosage. READ MORE
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5. Two novel combination therapies of glioblastoma multiforme from a Cx43 perspective : studies of in vitro models
Abstract : The group of patients suffering from the malignant brain tumour glioblastoma multiforme (GBM) have a median survival of only about one year. Thus, new treatment strategies are urgently needed. Gap junctions are intercellular channels, permitting intercellular transfer of water soluble substances. READ MORE