Search for dissertations about: "HDAC"

Showing result 16 - 20 of 37 swedish dissertations containing the word HDAC.

  2. 16. DNA microarray approaches to understanding the regulation and evolution of gene expression networks

    Author : Yongtao Xue-Franzen; Södertörns högskola; Karolinska Institutet; Karolinska Institutet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : DNA microarray technology allows biological and medical research to shift from investigation of individual functions of a few related genes to the whole genome level. This creates opportunities for discovery of complex and coordinated transcriptional networks in biological systems. READ MORE

  4. 17. Trypsinogen and neutrophil activation in acute Pancreatitis

    Author : Hannes Hartman Magnusson; Kirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute pancreatitis; trypsinogen activation; adhesion; neutrophil extracellular traps;

    Abstract : Background and aims: Acute pancreatitis (AP) is a common condition characterized by premature protease activation, abdominal pain and leakage of pancreatic enzymes to the circulation. Approximately 10% develop systemic inflammation and persistent organ failure. READ MORE

  5. 18. Transcriptomics and Proteomics Applied to Developmental Toxicology

    Author : Kim Kultima; Lennart Dencker; Timothy Gant; Uppsala universitet; []
    Keywords : Toxicology; 2D-DIGE; Valproic acid; PBDE-99; Flame retardant; Neural tube defects; Microarray; In vivo; In vitro; Biomarker; Brain growth spurt; Normalization; Mouse embryo; Toxicogenomics; Toxikologi;

    Abstract : Developmental toxicology is an important part of preclinical drug toxicology as well as environmental toxicology. Assessing reproductive and developmental toxicity is especially expensive and time demanding, since at least two generations of animals are needed in the tests. READ MORE

  6. 19. Regulation of vascular endothelial t-PA expression in inflammation: Potential target for pharmacological modulation

    Author : Pia Larsson; Göteborgs universitet; []
    Keywords : Vascular biology; Fibrinolysis; Inflammation; Histone acetylation;

    Abstract : The endogenous fibrinolytic system is important for preventing occluding thrombosis and subsequent tissue infarction. The main activator of the fibrinolytic system in the vascular compartment is tissue-type plasminogen activator (t-PA). READ MORE

  7. 20. Activity and mechanism of action of histone deacetylase inhibitors in synovial sarcoma

    Author : Limin Ma; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Synovial sarcoma is a rare but aggressive paediatric soft tissue sarcoma that is driven by the genomic rearrangement t(X;18)(p11.2;q11.2). The resulting fusion protein, SS18- SSX, exhibits oncogenic properties through protein-protein interactions that alter gene transcriptions and chromatin remodelling. READ MORE