Search for dissertations about: "HDAC1"

Showing result 1 - 5 of 7 swedish dissertations containing the word HDAC1.

  2. 1. Growth of parathyroid glands : genetic and functional aspects

    Author : Stiina Välimäki; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Parathyroid; primary hyperparathyroidism; secondary hyperparathyroidism; parathyroid carcinoma; chromosome 1; HDAC1; HRPT2; CASR; CAS; VDR; PTH; loss of heterozygosity; tumor suppressor gene; patch clamp; membrane potential; K channels;

    Abstract : Ca2+ is an essential ion with a variety of important functions in the body and it is crucial that the Ca2+ levels are precisely regulated. One of the hormones regulating these processes is parathyroid hormone (PTH) secreted from the parathyroid glands. READ MORE

  4. 2. Transcriptional Regulation of the Platelet-Derived Growth Factor beta-receptor

    Author : Anders Hackzell; Göteborgs universitet; []
    Keywords : PDGF; cell cycle; p73; p53; SV40; NF-Y; Sp1; Myc;

    Abstract : The Platelet Derived-Growth Factor (PDGF) receptors and ligands are expressed in cells of predominantly mesenchymal origin. Binding of the ligands to the receptors stimulates cell proliferation and other cellular responses such as differentiation and cell movement. READ MORE

  5. 3. Transcriptional Regulation of the Platelet-Derived Growth Factor B-receptor by p53 Family Members

    Author : Daniel Wetterskog; Göteborgs universitet; []
    Keywords : ;

    Abstract : Aims: The platelet-derived growth factor ?-receptor (PDGFRB) is critically involved in embryonic development and has a role in many diseases. In cells, signaling through PDGFRB affects growth, migration and death. READ MORE

  6. 4. Protein Acetylation – A Multifunctional Regulator of TGF-β Signaling

    Author : Maria Simonsson; Johan Ericsson; Eva Grönroos; Marikki Laiho; Uppsala universitet; []
    Keywords : Cell biology; TGF-β; Acetylation; Deacetylation; Acetyltransferase; HDAC; Smad; Transcription; Cellbiologi; MEDICINE; MEDICIN;

    Abstract : Transforming growth factor β (TGF-β) is a member of a large family of cytokines that regulate many crucial events in cells, including proliferation, differentiation, migration and apoptosis. Deregulated TGF-β signaling is associated with various forms of cancers and developmental disorders. READ MORE

  7. 5. Transcriptional regulation of genes expressed in the parathyroid gland

    Author : Anders Knutson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; Kirurgi; Surgery; Kirurgi; Surgery; kirurgi;

    Abstract : A dynamic interplay between promoter sequences and transcription factors ensures that genes are expressed at appropriate levels in each cell throughout the body. In the present investigation, the promoters of two different genes encoding proteins involved in parathyroid cell function and calcium homeostasis were studied. READ MORE