Search for dissertations about: "HEK293"

Showing result 11 - 15 of 40 swedish dissertations containing the word HEK293.

  2. 11. Hormonal Regulation of the Human CYP27A1 and CYP7B1 Genes

    Author : Wanjin Tang; Kjell Wikvall; Maria Norlin; Mats Gåfvels; Uppsala universitet; []
    Keywords : Pharmaceutical biochemistry; CYP27A1; CYP7B1; cholesterol; estrogen; androgen; prostate; glucocorticoid receptor; fetal development; Farmaceutisk biokemi;

    Abstract : CYP27A1 and CYP7B1 are widely expressed in various human tissues and are two key enzymes involved in the pathways for conversion of cholesterol to bile acids. Also, CYP27A1 is involved in bioactivation of vitamin D3 and CYP7B1 plays a role in 7alpha-hydroxylation of dehydroepiandrosterone and other steroids. READ MORE

  4. 12. Studies of the thioredoxin system in redox signaling and oxidative stress

    Author : Belén Espinosa Fernández; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Reactive oxygen species exert reversible posttranslational modifications in proteins containing redox sensitive thiols, thereby affecting several cellular processes and protein functions. Reductive enzyme systems, such as the thioredoxin system, can reverse most of these cysteine modifications. READ MORE

  5. 13. The ApoM/S1P-complex: its role in vascular inflammatory disease and interaction with S1P-receptors

    Author : Cecilia Frej; Malmö Klinisk kemi; []
    Keywords : lipoproteins; Apolipoproteins; Phospholipids; sepsis; Atherosclerosis;

    Abstract : HDL is believed to be protective against cardiovascular disease (CVD) via the reverse cholesterol transport and anti-inflammatory actions in the vessel. Apolipoprotein M (apoM) is an apolipoprotein mainly associated with HDL. Recently ApoM was proven tobe the main carrier of Sphingosine 1-phosphate (S1P) in circulation. READ MORE

  6. 14. The Role of Protein Kinase C in the Extracellular Ca2+-regulated Secretion of Parathyroid Hormone

    Author : Amos M. Sakwe; Lars Rask; Claes Juhlin; Uppsala universitet; []
    Keywords : Medical sciences; parathyroid hormone; Ca2 ; protein kinase C; calcium sensing receptor; ERK1 2; biosynthesis; secretion; MEDICIN OCH VÅRD; MEDICINE; MEDICIN;

    Abstract : Parathyroid hormone (PTH) is the major physiological regulator of the extracellular Ca2+ concentration ([Ca2+]o) in the body. The secretion of this hormone is suppressed at high [Ca2+]o. READ MORE

  7. 15. BRICHOS - a Novel Anti-Amyloid Chaperone : studies on pro-surfactant protein C

    Author : Hanna Willander; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : Lung surfactant protein C (SP-C) is a 35-residue, transmembrane (TM) peptide that is extremely hydrophobic and lacks known homologous proteins. Due to a high content in Val residues in the α-helical TM part, SP-C can spontaneously convert into β-sheet aggregates. READ MORE