Search for dissertations about: "HEK293"

Showing result 21 - 25 of 40 swedish dissertations containing the word HEK293.

  2. 21. Steroid metabolism in human reproductive organs

    Author : Anna Helena Karypidis; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Androgens are involved in the development of prostate cancer. Both UGT2B17 and CYP7B1 are involved in the metabolism of androgens and are highly abundant in the prostate. Deletion of the UGT2B17 gene is associated with low or undetectable urinary testosterone levels. READ MORE

  4. 22. Studies on the plasticity of glutamate receptors and its role for neuronal calcium homeostasis

    Author : Linda Westin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Calcium is the most important and versatile signaling molecule in the brain. Neurons are equipped with a variety of tools to utilize this simple ion in diverse ways. From controlling the millisecond fast neurotransmitter release, to reshaping neuronal structure and function. READ MORE

  5. 23. Analysis of signaling pathway activity in single cells using the in situ Proximity Ligation Assay

    Author : Linda Arngården; Ola Söderberg; Niclas Karlsson; Uppsala universitet; []
    Keywords : cell signaling; Wnt; Hippo; TGFB; Molekylär medicin; Molecular Medicine;

    Abstract : A cell that senses signals from its environment uses proteins for signal transduction via post translational modifications (PTMs) and protein- protein interactions (PPIs) from cell membrane into the nucleus where genes controlling cell proliferation, differentiation and apoptosis can be turned on or off, i.e. READ MORE

  6. 24. Glucocorticoid receptor cross-talk with NF-kappaB and AP-1 : functional role and mechanisms

    Author : Lars-Göran Bladh; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Glucocorticoid receptor; glucocorticoids; cross-talk; NF-kappaB; AP-1; cell cycle; cell proliferation;

    Abstract : The protein investigated in this thesis is the glucocorticoid receptor (GR), which is a ligand activated transcription factor that belongs to the superfamily of nuclear hormone receptors. The GR contains three functional independent domains, the N-terminal domain containing a major transactivation region, the central DNA binding domain (DBD) and the C-terminal domain that binds the hormone/ligand. READ MORE

  7. 25. Comparative analysis of the thermogenic protein UCP1 across the mammalian phylogeny

    Author : Michael James Gaudry; Martin Jastroch; Tobias Wang; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Uncoupling protein 1; Evolution; Non-shivering thermogenesis; Brown adipose tissue; molekylär biovetenskap; Molecular Bioscience;

    Abstract : Uncoupling protein 1 (UCP1) drives mitochondrial inefficiency to produce heat in mammalian brown adipose tissue (BAT). Many mammalian species rely on this form of adaptive non-shivering thermogenesis (NST) to defend high body temperatures in the cold. READ MORE